Exploration of Targeted Anti-tumor Therapy

Table 3. Ongoing trials investigating ICIs in thymic epithelial cancer patients (Source: Clinicaltrials.gov)

Combination	Treatment	Identifier/reference	Phase	Setting/line of treatment	Status	Estimated enrollment	Notes
Chemotherapy	Chemotherapy plus pembrolizumab	NCT04554524	II	First line	Recruiting	40	Open label, single group assignment
Single agent	Pembrolizumab	NCT02607631	II	Recurrent	Completed	33	Open label, single group assignment
	Nivolumab	NCT03134118	II	Recurrent	Recruiting	55	Open label, single group assignment
	Avelumab	NCT03076554	II	Recurrent	Recruiting	55	Open label, single group assignment
	Atezolizumab	NCT04321330	II	Recurrent	Recruiting	34	Open label, single group assignment
Radiotherapy	Pembrolizumab, docetaxel, cisplatin therapy followed by surgery/radiotherapy plus pembrolizumab	NCT03858582	II	Neo-adjuvant	Not yet recruiting	40	Non-randomized
Anti-angiogenic	Pembrolizumab plus sunitinib	NCT03463460	II	First line	Recruiting	40	Open label, single group assignment
Anti-angiogenic	Nivolumab plus vorolanib	NCT03583086	I/II	First line	Recruiting	177	Open label, single group assignment. thoracic tumors including thymic cancer

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Declarations

Author contributions

LC, FP, FM, AL, EL, FP wrote the manuscript and generated the figure and table. JA and RB contributed to the revisions of the manuscript. All authors approved the manuscript for publication.

Conflicts of interest

The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

Relevant financial activities outside the submitted work: JA reports receiving commercial research grants from Amphera and Roche, holds ownership interest (including patents) in Amphera BV, and is a consultant/advisory board member for Amphera, Boehringer Ingelheim, Bristol-Myers Squibb, Eli-Lilly, MSD, Takeda, Bayer, Astra Zeneca and Roche. RB is a consultant/advisory board member for Astra Zeneca, Boehringer Ingelheim, Novartis, MSD, Otsuka, Eli-Lilly, Roche. The other authors have no conflicts of interest to declare.

Ethical approval

Not applicable.

Consent to participate

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Consent to publication

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Availability of data and materials

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Funding

This research did not receive any specific grant from funding agencies in the public, commercial, or not-for-profit sectors.

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