Exploration of Targeted Anti-tumor Therapy

Table 2. Ongoing trials investigating ICIs in MPM (Source: Clinicaltrials.gov)

Combination	Treatment	Identifier/reference	Phase	Setting/line of treatment	Status	Estimated enrollment	Notes
Vaccine	Nivolumab plus galinpepimut-S	NCT04040231	I	Reccurent/relapsed	Recruiting	10	Open label, single group assignment
Single agent	Nivolumab	NCT03063450 (CONFIRM)	III	Relapsed	Active, not recruiting	336	Double-blind, placebo controlled
ICI	Nivolumab plus ipilimumab	NCT02899299 (CheckMate-743)	III	First Line	Active, not recruiting	606	Open label, randomized
ICI	Nivolumab/nivolumab plus ipilimumab	NCT02716272 (MAPS2)	II	Relapsed	Active, not recruiting	125	Open label, randomized
Chemotherapy	Durvalumab plus chemotherapy	NCT02899195 (PrE0505)	II	First line	Active, not recruiting	55	Open label, non-randomized
	Pembrolizumab/pembrolizumab plus chemotherapy	NCT02784171	II/III	First line	Active, not recruiting	520	Open label, randomized
	Nivolumab plus chemotherapy	NCT04177953	II	Adjuvant	Recruiting	92	Open label, randomized
	Atezolizumab plus gemcitabine	NCT04480372	II	Relapsed	Not yet recruiting	67	Open label, single group assignment
	Atezolizumab plus cisplatin and pemetrexed	NCT03228537	I	Neoadjuvant	Active, not recruiting	28	Open label, single group assignment
Radiotherapy	Pembrolizumab after radiation therapy	NCT02959463	I	Maintenance	Recruiting	24	Open label, non-randomized
Anti-angiogenic	Atezolizumab plus bevacizumab and chemotherapy	NCT03762018 (BEAT-meso)	III	First line	Recruiting	320	Open label, randomized
Photodynamic therapy	Nivolumab after intrapleural photodynamic therapy	NCT04400539	II	Maintenance	Not yet recruiting	20	Open label, single group assignment, pilot study

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Declarations

Author contributions

LC, FP, FM, AL, EL, FP wrote the manuscript and generated the figure and table. JA and RB contributed to the revisions of the manuscript. All authors approved the manuscript for publication.

Conflicts of interest

The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

Relevant financial activities outside the submitted work: JA reports receiving commercial research grants from Amphera and Roche, holds ownership interest (including patents) in Amphera BV, and is a consultant/advisory board member for Amphera, Boehringer Ingelheim, Bristol-Myers Squibb, Eli-Lilly, MSD, Takeda, Bayer, Astra Zeneca and Roche. RB is a consultant/advisory board member for Astra Zeneca, Boehringer Ingelheim, Novartis, MSD, Otsuka, Eli-Lilly, Roche. The other authors have no conflicts of interest to declare.

Ethical approval

Not applicable.

Consent to participate

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Consent to publication

Not applicable.

Availability of data and materials

Not applicable.

Funding

This research did not receive any specific grant from funding agencies in the public, commercial, or not-for-profit sectors.

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