Fanconi anaemia protein family and associated proteins

Approved gene nomenclature Alias Area of pathway Role in ICL
FANCA FA core complex Functions in the AG20 subcomplex with FANCG to promote FA core complex localisation and translocation
FANCB FA core complex Functions in the BL100 subcomplex with FANCL to improve efficiency of FANCD2/I ubiquitylation and provide structural scaffold
FANCC FA core complex Component of the CEF subcomplex with FANCE, FANCF to stabilize interactions between FANCD2/I complex and FA core complex and improve ubiquitylation efficiency
FANCE FA core complex Component of the CEF subcomplex with FANCC, FANCF to stabilize interactions between FANCD2/I complex and FA core complex and improve ubiquitylation efficiency
FANCF FA core complex Component of the CEF subcomplex with FANCC, FANCE to stabilize interactions between FANCD2/I complex and FA core complex and improve ubiquitylation efficiency
FANCG XRCC9 FA core complex Functions in the AG20 subcomplex with FANCA to promote FA core complex localisation and translocation
FANCL FA core complex Component of the BL100 subcomplex and E3 ubiquitin ligase controlling monoubiquitylation of FANCD2/I
FANCM FA core complex Binds FA core complex to chromatin at ICL sites
FANCT UBE2T FA core complex E2 ubiquitin ligase controlling monoubiquitylation of FANCD2/I
FANCD2 FANCD2/I complex Initiates unhooking by nucleases
FANCI FANCD2/I complex Initiates unhooking by nucleases
SLX4 FANCP Unhooking Recruits and regulates nuclease activity during unhooking
ERCC4 FANCQ, XPF Unhooking Key endonuclease mediating incision of crosslink during unhooking
MAD2L2 FANCV, REV7 TLS Subunit of the TLS extension polymerase POLζ
BRIP1 FANCJ, BACH1 TLS/HR Regulates pathway choice between TLS and HR repair
BRCA2 FANCD1 HR Recruitment of RAD51 to ssDNA
PALB2 FANCN HR Mediates loading of BRCA1/2 complex on to single stranded DNA
RAD51C FANCO HR RAD51 nucleoprotein filament assembly
RAD51 FANCR HR Forms nucleoprotein filaments which mediate template homology search and strand exchange
BRCA1 FANCS HR CMG helicase eviction, HR pathway promotion and TLS inhibition in complex with FANCJ, complex formation with BRCA2 during HR
XRCC2 FANCU HR RAD51 nucleoprotein filament assembly
RFWD3 FANCW HR Mediates RPA dynamics to promote HR
FAAP10* MHF2, CENPX, STRA13 FA core complex Localization of FANCM to chromatin
FAAP16* MHF1, CENPS, APITD1 FA core complex Localization of FANCM to chromatin
FAAP20* FA core complex Promotes stability of the AG20 subcomplex
FAAP24* FA core complex Associates with FANCM to mediate DNA binding of the FA core complex
FAAP100* FA core complex Functions within the BL100 subcomplex to provide structural scaffold

Genes are not true FA family members as mutations have not been documented in FA patients, but are members of the family of FA Associated Proteins, and are required for the successful function of the FA pathway. FAAP: Fanconi anaemia associated protein