Table Info

Table 2.

Key trials of platinum agents in advanced/metastastic BC with gBRCA1/2 mutations

Trial	Population	Phase	Treatment arms	Outcomes
TNT (NCT00532727) [46]	Advanced/metastatic TNBC	III	Carboplatin vs. docetaxel	Overall population: ORR 31.4% (carboplatin) vs. 34% (docetaxel); PFS 3.1 months (carboplatin) vs. 4.4 months (docetaxel); OS 3.1 months (carboplatin) vs. 4.4 months (docetaxel) gBRCA1/2 subgroup: ORR 68% (carboplatin) vs. 33% (docetaxel); PFS 12.8 months (carboplatin) vs. 12 months (docetaxel)
TBCRC009 (NCT00483223) [47]	Metastatic TNBC	II	Cisplatin vs. carboplatin	Overall population: ORR 25.6% (study population); ORR 32.6% (cisplatin) vs. 18.7% (carboplatin) gBRCA1/2 subgroup: ORR 54.6%

BC: breast cancer; gBRCA1/2: germline mutations in the BReast CAncer (BRCA) 1/2 gene; ORR: objective response rate; OS: overall survival; PFS: progression-free survival; TNBC: triple negative breast cancer

Declarations

Author contributions

VP and SC: Conceptualization, Investigation, Writing—original draft, Writing—review & editing. CA: Visualization, Conceptualization, Writing—review & editing. TB: Data curation, Writing—review & editing. RTdS: Conceptualization, Writing—review & editing. ST, LAR, GNC, HLP, CP, and Leila C: Writing—review & editing. Luís C: Visualization, Conceptualization, Writing—review & editing.

Conflicts of interest

The authors declare no conflicts of interest.

Ethical approval

This study was approved by the ethics committee of COMISSÃO DE ÉTICA DO CAML.

Consent to participate

The consent to participate has been waived by the IRB of COMISSÃO DE ÉTICA DO CAML given the retrospective nature of this study.

Consent to publication

Not applicable.

Availability of data and materials

The raw data supporting the conclusions of this manuscript will be made available by the authors (Vanessa Patel, vanessacpatel@gmail.com) , without undue reservation, to any qualified researcher.

Funding

Not applicable.

Copyright

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