Exploration of Targeted Anti-tumor Therapy

Table 7. Ongoing clinical trials of other targeted therapies in UC

Drugs	Targets	Comnonation	Conditions	Phase	NCT
Abemaciclib	CDK4/6	Null	UC	I	NCT03837821
Belinostat	HDAC	Durvalumab + tremelimumab	UC	I	NCT05154994
Tazemetostat	EZH2	Pembrolizumab	UC	I/II	NCT03854474
Trilaciclib	CDK4/6	Gemcitabine + cisplatin/carboplatin + avelumab	UC	II	NCT04887831
Vactosertib	TGF-β	Durvalumab	UC	II	NCT04064190
Vorinostat	HDAC 1, 2, 3, 6, 7, 11	Docetaxel	UC	I	NCT00565227

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Null in Combination indicates that the trial is monotherapy. UC: urothelial carcinoma; CDK4/6: cyclin-dependent kinases 4 and 6; HDAC: histone deacetylase; EZH2: enhancer of zeste homolog; TGF-β: transforming growth factor β

Declarations

Author contributions

SS, LZ, and KL contributed equally to: Writing—original draft, Writing—review & editing. ML, JZ, DJ, DW, ZS, and PX: Investigation, Writing—review & editing. JY and ZZ: Conceptualization, Writing—review & editing, Supervision. All authors read and approved the submitted version.

Conflicts of interest

The authors declare that they have no conflicts of interest.

Ethical approval

Not applicable.

Consent to participate

Not applicable.

Consent to publication

Not applicable.

Availability of data and materials

Not applicable.

Funding

This study was supported by the Shaanxi Province Key Industry Chain Project [2022ZDLSF05-14]. The funder played no role in the study design, data collection and analysis, decision to publish, or in the preparation of the manuscript.

Copyright

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