Exploration of Targeted Anti-tumor Therapy

Table 6. Ongoing clinical trials of PARP-targeted therapy in UC

Drugs	Targets	Combinations	Conditions	Phase	NCT
Niraparib	PARP	Dostarlimab	UC	II	NCT04779151
Niraparib	PARP	Atezolizumab	UC	I/II	NCT03869190
Olaparib	PARP	Null	Met/Adv UC	II	NCT03375307
Olaparib	PARP	EP0057	UC	I/II	NCT02769962
Olaparib	PARP	Durvalumab	UC \| MIBC	I	NCT02546661
Olaparib	PARP	Ceralasertib	Met UC	II	NCT03682289
Talazoparib	PARP	Avelumab	UC	II	NCT04678362
Veliparib	PARP	Paclitaxel, carboplatin	UC	I	NCT01366144

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Null in combination indicates that the trial is monotherapy. PARP: poly ADP-ribose polymerase; MIBC: muscle-invasive bladder cancer; UC: urothelial carcinoma; Adv: advanced; Met: metastatic. |: and

Declarations

Author contributions

SS, LZ, and KL contributed equally to: Writing—original draft, Writing—review & editing. ML, JZ, DJ, DW, ZS, and PX: Investigation, Writing—review & editing. JY and ZZ: Conceptualization, Writing—review & editing, Supervision. All authors read and approved the submitted version.

Conflicts of interest

The authors declare that they have no conflicts of interest.

Ethical approval

Not applicable.

Consent to participate

Not applicable.

Consent to publication

Not applicable.

Availability of data and materials

Not applicable.

Funding

This study was supported by the Shaanxi Province Key Industry Chain Project [2022ZDLSF05-14]. The funder played no role in the study design, data collection and analysis, decision to publish, or in the preparation of the manuscript.

Copyright

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