Exploration of Targeted Anti-tumor Therapy

Table 3. Ongoing clinical trials of VEGF-targeted therapy in UC

Drugs	Targets	Combinations	Conditions	Phase	NCT
Bevacizumab	VEGF	MK-7684A	UC	II	NCT05007106
Bevacizumab	VEGF	Dasatinib	Met/Adv UC	I	NCT04164069
Lenvatinib	VEGFR1–3	GI-101	Met/Adv UC	I/II	NCT04977453
Lenvatinib	VEGFR1–3	MK-7684A	UC	II	NCT05007106
Ramucirumab	VEGFR2	TRK-950	UC	I	NCT03872947

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VEGF: vascular endothelial growth factor; UC: urothelial carcinoma; VEGFR1–3: vascular endothelial growth factor receptor 1–3; Adv: advanced; Met: metastatic; MK-7684A: the combination of vibostolimab and pembrolizumab; GI: SIM0323

Declarations

Author contributions

SS, LZ, and KL contributed equally to: Writing—original draft, Writing—review & editing. ML, JZ, DJ, DW, ZS, and PX: Investigation, Writing—review & editing. JY and ZZ: Conceptualization, Writing—review & editing, Supervision. All authors read and approved the submitted version.

Conflicts of interest

The authors declare that they have no conflicts of interest.

Ethical approval

Not applicable.

Consent to participate

Not applicable.

Consent to publication

Not applicable.

Availability of data and materials

Not applicable.

Funding

This study was supported by the Shaanxi Province Key Industry Chain Project [2022ZDLSF05-14]. The funder played no role in the study design, data collection and analysis, decision to publish, or in the preparation of the manuscript.

Copyright

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