Exploration of Targeted Anti-tumor Therapy

Table 1. Ongoing clinical trials of FGFR-targeted therapy in UC

Drugs	Targets	Combination	Conditions	Phase	NCT
Erdafitinib	FGFR2/3	Null	Rec UC \| FGFR3 gene mutation	II	NCT04917809
Erdafitinib	FGFR2/3	Null	UC	I	NCT05316155
Erdafitinib	FGFR2/3	Null	UC	I	NCT05567185
Erdafitinib	FGFR2/3	Gemcitabine + mitomycin C	UC	II	NCT04172675
Erdafitinib	FGFR2/3	Atezolizumab	UC \| MIBC	II	NCT05564416
Erdafitinib	FGFR2/3	Enfortumab vedotin	Adv UC	I	NCT04963153
Rogaratinib	FGFR1–3	Null	UC	II	NCT04040725
Rogaratinib	FGFR 1-3	Atezolizumab	UC	I	NCT03473756
Pemigatinib	FGFR1–3	Null	Rec UC \| NMIBC	II	NCT03914794
Infigratinib	FGFR1–3	Null	Solid Tumor	II	NCT05019794
Infigratinib	FGFR1–3	Null	Adv/Met malignant solid neoplasm	II	NCT04233567
Infigratinib	FGFR1–3	Null	Adv solid tumor	I/II	NCT05222165
Infigratinib	FGFR1–3	Null	UC \| NMIBC	Not applicable	NCT02657486
Futibatinib	FGFR1–4	Null	UC	I/II	NCT02052778
ICP-192	FGFR 1–4	Null	UC	II	NCT04492293
ICP-192	FGFR 1–4	Null	UC	I/II	NCT04565275
TYRA-300	FGFR3	Null	UC	I	NCT05544552

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Null in Combination indicates that the trial is monotherapy. FGFR: fibroblast growth factor receptor; UC: urothelial carcinoma; MIBC: muscle-invasive bladder cancer; NMIBC: non-MIBC; Adv: advanced; Met: metastatic; Rec: recurrent; NCT: national clinical trial; ICP-192: gunagratinib; |: and

Declarations

Author contributions

SS, LZ, and KL contributed equally to: Writing—original draft, Writing—review & editing. ML, JZ, DJ, DW, ZS, and PX: Investigation, Writing—review & editing. JY and ZZ: Conceptualization, Writing—review & editing, Supervision. All authors read and approved the submitted version.

Conflicts of interest

The authors declare that they have no conflicts of interest.

Ethical approval

Not applicable.

Consent to participate

Not applicable.

Consent to publication

Not applicable.

Availability of data and materials

Not applicable.

Funding

This study was supported by the Shaanxi Province Key Industry Chain Project [2022ZDLSF05-14]. The funder played no role in the study design, data collection and analysis, decision to publish, or in the preparation of the manuscript.

Copyright

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