Exploration of Targeted Anti-tumor Therapy

Table 1. Main trials including ARIs for PC treatment

Drug	Patient stage	Study	Benefit
Enzalutamide	mCRPCa post-CT	AFFIRM 2012	+ OS
Enzalutamide	mCRPCa before-CT	PREVAIL 2014	+ PFS
Enzalutamide	mHSPCa	ENZAMET 2019	+ OS
Enzalutamide	mHSPCa	ARCHES 2019	+ OS
Enzalutamide	nmCRPCa, PSADT ≤ 10 ms	PROSPER 2018	+ OS
Enzalutamide	nmHSPCa, PSADT ≤ 9 ms	EMBARK 2020	+ MFS
Apalutamide	nmCRPCa, PSADT ≤ 10 ms	SPARTAN 2018	+ MFS
Apalutamide	mHSPCa	TITAN 2019	+ OS
Darolutamide	nmCRPCa, PSADT ≤ 10 ms	ARAMIS 2019	+ OS
Darolutamide	mHSPC	ARASENS 2022	+ OS

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CT: computed tomography; +: increasing benefit; mHSPC: metastatic hormone sensitive prostate cancer

Declarations

Acknowledgments

We thank Giovanni Campodonico for providing graphic technical support.

Author contributions

FC: Conceptualization, Data curation, Writing—original draft, Writing—review & editing. LF: Conceptualization, Writing—original draft, Writing—review & editing. VC: Resources, Visualization. CI: Supervision, Validation.

Conflicts of interest

The authors declare that they have no conflicts of interest.

Ethical approval

Not applicable.

Consent to participate

Not applicable.

Consent to publication

Not applicable.

Availability of data and materials

Not applicable.

Funding

Not applicable.

Copyright

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