Exploration of Targeted Anti-tumor Therapy

Table 1. Demographic characteristics of patients at baseline and follow up

Parameters	Baseline (n = 59), n (%)	Follow-up (n = 27), n (%)
Age in years	64.3 (9.1)^*
Male gender	56 (94.9)
ECOG status
0–1	33 (55.9)	18 (66.7)
2–4	26 (44.1)	09 (33.3)
KPS
90–100	20 (33.9)	13 (48.1)
80 and below	39 (66.1)	14 (51.9)
Smoking status
Never smoker	02 (3.4)
Current smoker	52 (88.1)
Former smoker	05 (8.5)
Smoking index	551.8 (376.4)^*
Comorbidities	25 (42.4)
TNM stage
IIIB	16 (27.1)
IIIC	08 (13.6)
IVA	30 (50.8)
IVB	05 (8.5)
RSB score	9.9 (5.8)^*	4.1 (4.5)^*
TSB score	16.9 (9.9)^*	8.2 (8.0)^*
cfDNA detectability	13 (22.0)	18 (66.7)
cfDNA levels (pg/μL)	77.3 (181.3)^*	244.3 (279.8)^*
RECIST 1.1 change
PR		18 (66.7)
SD		05 (18.5)
PD		4 (14.8)

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^* Data represented as mean (StdDev). Current smoker: smoked cigarettes/bidis within the last 6 months; never smoker: smoked less than 100 cigarettes in his/her lifetime; former smoker: smoked cigarettes/bidis before 6 months; KPS: Karnofsky performance scale; PR: partial response; SD: stable disease; PD: progressive disease; ECOG: Eastern Co-operative Oncology Group; TNM: tumor-nodes-metastasis; RSB: respiratory symptom burden; TSB: total symptom burden; cfDNA: cell free DNA; RECIST: response evaluation criteria in solid tumours

Supplementary materials

The supplementary material for this article is available at: https://www.explorationpub.com/uploads/Article/file/1002232_sup_1.pdf.

Declarations

Author contributions

NR: Conceptualization, Methodology, Investigation, Formal analysis, Writing—original draft, Writing—review & editing. PG: Investigation, Writing—original draft, Writing—review & editing, Validation. AB: Conceptualization, Methodology, Investigation, Writing—review & editing, Validation, Supervision. KTP, MG, and RK: Resources, Writing—review & editing, Supervision. NS: Conceptualization, Methodology, Formal analysis, Writing—original draft, Writing—review & editing, Validation, Supervision. All authors read and approved the submitted version.

Conflicts of interest

The authors declare that they have no conflicts of interest.

Ethical approval

This study has been approved by the Ethics Committee PGIMER IEC. Reference No.: NK/4781/DM/188. This study complies with the Declaration of Helsinki.

Consent to participate

Informed consent to participate in the study was obtained from all participants.

Consent to publication

Not applicable.

Availability of data and materials

The datasets for this manuscript are not publicly available because of institutional and national regulatory guidelines. However, reasonable requests for accessing the datasets should be directed to the corresponding author.

Funding

Not applicable.

Copyright

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