Exploration of Targeted Anti-tumor Therapy

Reference	Treatment	TM/TC	PD-L1 cut-off	PD-L1 positive cases	Primary endpoint	mOS	mPFS	ORR
Giaccone et al. [44]	Pembrolizumab	0/40	PD-L1^high: ≥ 50%	10/37 (27%)	ORR	Un	4.2	-
PD-L1^low: 1–49%	27/37 (73%)	15.5	2.9
Cho et al. [43]	Pembrolizumab	7/26	PD-L1^high: ≥ 50%	14/24 (58.3%)	ORR	-	-	35.7%
PD-L1^low: 1–49%	10/24 (41.7%)	-	-	NR

Declarations

Author contributions

SL: Conceptualization, Methodology, Investigations, Writing—original draft, Writing—review & editing. MA and SC: Methodology, Investigations. RF: Conceptualization, Methodology, Investigations, Writing—original draft, Writing—review & editing, Supervision.

Conflicts of interest

The authors declare that they have no conflicts of interest.

Ethical approval

According to Italian law, the content of this article does not require ethical approval.

Consent to participate

According to Italian law, the content of this article does not require consent to participate. The images could be used for diulgative purpose for the italian law, since they are totally anonymized.

Consent to publication

Not applicable.

Availability of data and materials

Not applicable.

Funding

Not applicable.

Copyright

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