Exploration of Targeted Anti-tumor Therapy

Table 2. PD-L1 expression on TETs

Reference	TM	TC	Antibody of PD-L1	IHC staining criteria of positivity	TM positivity rate	TC positivity rate
Weissferdt et al. [47]	74/100 (74.00%)	26/100 (26.00%)	Clone EPR4877	MS > 5%	64.00%	54.00%
Arbour et al. [48]	12/23 (52.17%)	11/23 (47.83%)	Clone E1L3N	MS > 25%	92.00%	36.00%
Suster et al. [49]	-	21	Clone SP142	MS > 50%	NA	71.40%
Higuchi et al. [50]	31/39 (79.50%)	8/39 (20.50%)	Clone 28-8	MS ≥ 1%	51.60%	62.50%
Wei et al. [51]	100/169 (59.20%)	69/169 (40.80%)	Clone E1L3N	MS > 50%	36.00%	37.00%
Duan et al. [52]	20/33 (60.60%)	13/33 (39.40%)	Clone Ab58810	Intensity of staining score (1–3); median value of all scores as the cut-off value	65.00%	46.20%
Funaki et al. [53]	-	43	Clone SP142	MS > 50%	NA	60.50%
Katsuya et al. [54]	101/139 (72.60%)	38/139 (27.40%)	Clone E1L3N	H-score: score 3 [staining intensity (0–3) × % of positive cells (0–100%)]	23.00%	70.00%
Padda et al. [55]	65/69 (94.20%)	4/69 (5.80%)	Clone 15	Score 3 (intensity of MS 0–3)	68.00%	75.00%
Marchevsky et al. [56]	38/46 (82.60%)	8/46 (17.40%)	Clone SP142	MS ≥ 6%	92.00%	50.00%
Enkner et al. [8]	37/72 (51.30%)	35/72 (48.70%)	Clone E1L3N	H-score (cut-off value NA)	89.00%	53.00%
Katsuya et al. [57]	12/30 (40.00%)	18/30 (60.00%)	Clone E1L3N	Score ≥ 1 (intensity of MS 0–3)	67.00%	41.00%
Yokoyama et al. [58]	82	-	Clone EPR1161	Youden’s index > 38%	53.70%	NA
Tiseo et al. [59]	87/107 (81.30%)	20/107 (18.70%)	Clone E1L3N	H-score: score 3 (intensity of MS 0–3)	18.00%	65.00%
Owen et al. [60]	32/35 (91.40%)	3/35 (8.60%)	Clone 22C3	Score 1 (intensity of MS 0–5)	81.00%	100.00%
Hakiri et al. [61]	81	-	Clone SP142	MS ≥ 1%	27.00%	NA
Guleria et al. [62]	84	-	Clone SP263	MS > 25%	82.00%	NA
Chen et al. [63]	40/70 (57.00%)	30/70 (43.00%)	Clone SP142	MS ≥ 5%	37.50%	76.70%
Bagir et al. [64]	38/44 (86.30%)	6/44 (13.70%)	Clone AM26531AF-N	MS > 5%	81.60%	83.30%
Ishihara et al. [65]	55/66 (83.30%)	11/66 (16.70%)	Clone SP263	MS > 25%	92.70%	72.70%
Berardi et al. [66]	63/68 (92.60%)	5/68 (7.40%)	Clone 28-8	MS > 1%	Overall: 25.00%

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NA: not available; -: blank cells

Declarations

Author contributions

SL: Conceptualization, Methodology, Investigations, Writing—original draft, Writing—review & editing. MA and SC: Methodology, Investigations. RF: Conceptualization, Methodology, Investigations, Writing—original draft, Writing—review & editing, Supervision.

Conflicts of interest

The authors declare that they have no conflicts of interest.

Ethical approval

According to Italian law, the content of this article does not require ethical approval.

Consent to participate

According to Italian law, the content of this article does not require consent to participate. The images could be used for diulgative purpose for the italian law, since they are totally anonymized.

Consent to publication

Not applicable.

Availability of data and materials

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Funding

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Copyright

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