Table Info

Table 6.

Summary of clinical investigations in PRIT of NHL

Targeting antibody	Main finding	Reference
Anti-CD20 C2B8/SA	Anti-CD20 antibody (C2B8) conjugated to SA followed by 30 mCi/m² or 50 mCi/m² of ⁹⁰Y-DOTA-biotin was administered to patients with relapsed NHL in a phase I/II study. Six of seven patients exhibited objective responses (3 CR and 1 PR). Five of the seven patients showed transient grade III hematological toxicity. The estimate of tumor to whole body dose ratio was 38:1.	[67]
Anti-CD20 B9E9(scFv)₄ SA	Anti-CD20 B9E9(scFv)₄ SA followed by ⁹⁰Y-DOTA-biotin was evaluated in patients with relapsed NHL in a phase I study. Three of fourteen patients who received ⁹⁰Y-DOTA-biotin had objective tumor responses (2 CR and 1 PR). No significant hematologic toxicities were reported. The ratio of average tumor to whole-body radiation dose was 49:1.	[68]

Declarations

Acknowledgments

We thank Kumiko Fukushima for secretarial assistance (Kumamoto University).

Author contributions

HG: Conceptualization, Writing—original draft, Writing—review & editing, Supervision. SO: Conceptualization, Writing—review & editing, Supervision. YS: Writing—review & editing. All authors read and approved the submitted version.

Conflicts of interest

The authors declare that they have no conflicts of interest.

Ethical approval

Not applicable.

Consent to participate

Not applicable.

Consent to publication

Not applicable.

Availability of data and materials

Not applicable.

Funding

Not applicable.

Copyright

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