Exploration of Targeted Anti-tumor Therapy

Table 1. The direct effects of anti-CD99 mAbs in T-ALL

Antibody name	Isotype	Epitope	Effect on T-ALL	Effect on normal cells
DN16	mIgG1	LPDNENKK	Induces apoptosis	Not performed
0662	mIgG3	GSFSDADLA	Induces apoptosis	Not performed
12E7	mIgG1	DGEN	No apoptosis	Not performed
D44	mIgM	Not reported	No apoptosis	Not performed
Ad20	mIgM	Not reported	Induces apoptosis	No apoptosis
10A1	hIgG1^※	ENDDPRPPNPPKPM	Induces apoptosis	No apoptosis
YG32	mIgG	RPPNPPK	No apoptosis Induces homotypic aggregation	Not performed
MT99/3	mIgG2a	Not reported	No apoptosis Induces homotypic aggregation	Not performed
MT99/1	mIgM	Not reported	Induces homotypic aggregation and apoptosis	Not performed
MT99/2	mIgM	Not reported	No homotypic aggregation and no apoptosis	Not performed

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^※ Tetravalent antibody. hIgG1: human IgG1

Declarations

Author contributions

KK: Conceptualization, Writing—original draft, Writing—review & editing. WK: Writing—review & editing. NT: Conceptualization, Writing—original draft, Writing—review & editing, Supervision. All authors have read and approved the submitted version.

Conflicts of interest

The authors declare that they have no conflicts of interest.

Ethical approval

Not applicable.

Consent to participate

Not applicable.

Consent to publication

Not applicable.

Availability of data and materials

Not applicable.

Funding

This work was financially supported by the Office of the Permanent Secretary, Ministry of Higher Education, Science, Research and Innovation (OPS MHESI), Thailand Science Research and Innovation (TSRI) [RGNS 64—068]; and partially supported by Chiang Mai University to NT; the Faculty of Associated Medical Sciences at Chiang Mai University (2022 budget revenue to NT); and the Distinguished Research Professor Grant of the National Research Council of Thailand [NRCT808/2563]; KK has received the Teaching Assistant and Research Assistant (TA/RA) Scholarship from the Graduate School, Chiang Mai University. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.

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