Examples of translationally regulated genes with relevance to mature B-cell neoplasms

Gene(s) Protein function Association with B-cell neoplasms Evidence for translational control via eIFs Refs
MYC Cell growth
  • Translocations are a hallmark of Burkitt’s lymphoma

  • Recurrent mutations in double/triple hit DLBCL

  • Increased expression following BCR stimulation is associated with increased mRNA translation

  • Inhibition of eIF4A reduces MYC expression in B-cell lymphoma cell lines

  • Inhibition of eIF4E reduces MYC mRNA translation and nuclear export in DLBCL cell lines

[96, 101104]
MCL1 Cell survival (anti-apoptotic)
  • Expression induced following BCR stimulation

  • Inhibition of eIF4A reduces MCL1 expression in B-cell lymphoma cell lines

[103]
BCL2 Cell survival (anti-apoptotic)
  • Translocations are a hallmark of FL

  • Recurrent translocations in GCB-DLBCL and double/triple hit DLBCL

  • Inhibition of eIF4E reduces BCL2 mRNA translation and nuclear export in DLBCL cell lines

[101]
CCND1 Cell cycle progression
  • Translocations are a hallmark of mantle cell lymphoma

  • Inhibition of eIF4A reduces cyclin D1 expression in B-cell lymphoma cell lines

[103]
BCL6 Transcriptional repression
  • Recurrent translocations in double/triple hit DLBCL

  • Inhibition of eIF4E reduces BCL6 mRNA translation and nuclear export in DLBCL cell lines

[101]
CARD11, BCL10, MALT1 CBM complex components which control NF-κB activation
  • Recurrent mutations in subset of ABC-DLBCL

  • Mediates NF-κB activation downstream of BCR

  • Inhibition of eIF4A reduces CBM complex expression in DLBCL cell lines

[102]