Change in biomarkers of serum after supplementation of vitamin D in breast cancer patients
Biomarkers
Placebo
Vitamin D
Absolute treatment effecta
Baseline
2 Months
Pc
Baseline
2 Months
Pc
Placebo
Vitamin D
Pb
25(OH)D (ng/mL)
15.3 ± 2.2
13.4 ± 2.2
0.59
28 ± 2.6
39 ± 3.5
0.004*
–1.9 ± 0.9
11 ± 3.1
0.001*
TNF-α (pg/mL)
32.6 ± 8
25.6 ± 3.2
0.19
13.4 ± 1.1
14.5 ± 1.6
0.96
7 ± 2.1
1.1 ± 2.1
0.18
TGF-β (pg/mL)
123.4 ± 9
133.8 ± 10
0.24
293.8 ± 48.8
288 ± 42.9
0.84
10.4 ± 7.1
–5.6 ± 33.4
0.64
TAC (U/mL)
45.2 ± 11.5
29.2 ± 8.3
0.001*
48.9 ± 13.3
63.5 ± 13.3
0.004*
–16 ± 8.4
14.6 ± 8.9
0.017*
a Absolute treatment effect is the absolute change from baseline to follow-up in the treatment group minus the absolute change from baseline to follow-up in the placebo group; bP values for differences between the treatment and placebo groups; cP values for difference between baseline visit and post-intervention values; *P value < 0.05; values are mean ± SD
Declarations
Acknowledgment
We thank the Nutrition and Metabolic Diseases Research Center, Ahvaz Jundishapur University of Medical Sciences, Iran, for sample collection.
Author contributions
SAH: Conceptualization. MT: Methodology, Formal analysis, Investigation, Writing—original draft. AJ: Methodology, Formal analysis, Investigation, Writing—review & editing, Supervision. MV: Writing—review & editing. All authors critically revised the manuscript, agreed to be fully accountable for ensuring the integrity and accuracy of the work, and read and approved the final manuscript.
Conflict of interest
The authors declare that they have no conflicts of interest.
Ethical approval
All procedure performed in this study was approved by Ahvaz Jundishapur University of the Medical Sciences Ethics Committee (IR.AJUMS.REC.1398.876), and this study complies with the Declaration of Helsinki.
Consent to participate
Informed consent to participate in the study was obtained from all participants.
Consent to publication
Not applicable.
Availability of data and materials
Not applicable.
Funding
This work was supported and granted by the Nutrition and Metabolic Diseases Research Center, Ahvaz Jundishapur University of Medical Sciences [NRC-9820], Ahvaz, Iran. The funding provider plays a role in study design, and data collection, apart from these, there is no other contribution.
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