Key considerations for linker motifs described
| Structure | Linker type | Key points |
|---|---|---|
 |
Alkyl/PEG | - High synthetic accessibility and commercial availability- Enable fine-tuning of linker length- Flexible |
 |
Rigidifying groups | - Potential potency improvements- More favourable physical properties- Conformational restriction |
 |
Clickable groups | - Facilitates library synthesis- High-yielding synthesis- Potential H-bond interactions in the TC |
 |
CLIPTACs | - Assembled from lower MW precursors- More favourable physical properties- Compounds must be administered separately to avoid clicking |
 |
Photoswitches | - High spatiotemporal control- May alleviate toxicity- Continuous irradiation may be required if photostates are not bistable |