Key considerations for linker motifs described

Structure Linker type Key points
Alkyl/PEG - High synthetic accessibility and commercial availability
- Enable fine-tuning of linker length
- Flexible
Rigidifying groups - Potential potency improvements
- More favourable physical properties
- Conformational restriction
Clickable groups - Facilitates library synthesis
- High-yielding synthesis
- Potential H-bond interactions in the TC
CLIPTACs - Assembled from lower MW precursors
- More favourable physical properties
- Compounds must be administered separately to avoid clicking
Photoswitches - High spatiotemporal control
- May alleviate toxicity
- Continuous irradiation may be required if photostates are not bistable