Key considerations for linker motifs described
| Structure | Linker type | Key points |
|---|---|---|
 | Alkyl/PEG | - High synthetic accessibility and commercial availability- Enable fine-tuning of linker length- Flexible |
 | Rigidifying groups | - Potential potency improvements- More favourable physical properties- Conformational restriction |
 | Clickable groups | - Facilitates library synthesis- High-yielding synthesis- Potential H-bond interactions in the TC |
 | CLIPTACs | - Assembled from lower MW precursors- More favourable physical properties- Compounds must be administered separately to avoid clicking |
 | Photoswitches | - High spatiotemporal control- May alleviate toxicity- Continuous irradiation may be required if photostates are not bistable |
All authors contributed to the conception and organisation of this review. RT prepared the first draft of the manuscript, and all authors contributed to the writing and development of additional sections. All authors contributed to manuscript revision and approved the submitted version.
The authors declare that they have no conflicts of interest.
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This work was supported by AstraZeneca with a CASE award, and the EPSRC with a CASE Conversion grant (EP/R513325/1). AstraZeneca approved the final submitted version of the manuscript. The industrial supervisor/author (CF), together with the other authors, contributed to the design, writing, proof-reading and submission of this review.
© The Author(s) 2020.