Key considerations for linker motifs described
Structure | Linker type | Key points |
---|---|---|
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Alkyl/PEG | - High synthetic accessibility and commercial availability- Enable fine-tuning of linker length- Flexible |
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Rigidifying groups | - Potential potency improvements- More favourable physical properties- Conformational restriction |
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Clickable groups | - Facilitates library synthesis- High-yielding synthesis- Potential H-bond interactions in the TC |
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CLIPTACs | - Assembled from lower MW precursors- More favourable physical properties- Compounds must be administered separately to avoid clicking |
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Photoswitches | - High spatiotemporal control- May alleviate toxicity- Continuous irradiation may be required if photostates are not bistable |