Comparison of the physical properties of CLIPTAC precursor molecules (71–73) to published BET degraders (1–3)

Compound MW cLogP TPSA
71 572 1.2 173
72 609 5.9 111
73 586 6.5 130
MZ1 (1) 1003 4.9 211
ARV-825 (2) 924 4.8 205
dBET1 (3) 785 2.5 194