Exploration of Targeted Anti-tumor Therapy

Interacting binding sites	Functions	References
Thr663	Gatekeeper residue	[26, 42]
Cys666	ATP binding site residue	[26]
Tyr546, Trp550	Regulates JMD to maintain an autoinhibitory state	[39]
Asp796	Form the DFG-motif, regulates the activation loop to maintain an autoinhibitory conformation	[8]
Met637, Leu588	Residues of CSF1R specificity	[26, 42]
Lys616, Glu633	Forms salt bridge regulating activation	[34]
Leu640, Ile646, Leu769, Leu785, Val596, Cys774, Ile794	Forms a hydrophobic pocket	[34]

Declarations

Author contributions

ZA: Conceptualization, Writing—original draft, Writing—review & editing, Investigation, Methodology. RPG: Supervision, Writing—review & editing. AR: Project administration. ZR: Data curation, Software, Validation.

Conflicts of interest

The authors declare that they have no conflicts of interest.

Ethical approval

Not applicable.

Consent to participate

Not applicable.

Consent to publication

Not applicable.

Availability of data and materials

Not applicable.

Funding

Not applicable.

Copyright

References

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