Significant interacting residues of CSF1R and their functions

Interacting binding sitesFunctionsReferences
Thr663Gatekeeper residue[26, 42]
Cys666ATP binding site residue[26]
Tyr546, Trp550Regulates JMD to maintain an autoinhibitory state[39]
Asp796Form the DFG-motif, regulates the activation loop to maintain an autoinhibitory conformation[8]
Met637, Leu588Residues of CSF1R specificity[26, 42]
Lys616, Glu633Forms salt bridge regulating activation[34]
Leu640, Ile646, Leu769, Leu785, Val596, Cys774, Ile794Forms a hydrophobic pocket[34]