Table Info

Table 3.

Molecular alterations in ARID1A⁺ tumors

Tissue used for analysis	Molecular alterations in ARID1A	Hystology
Primary disease (diagnosis)	ARID1A-PTAR1 truncation, S2249*	Ovarian (clear cell)
	L1731fs4; Q372fs19	Endometrial (endometrioid)
	N104fs*7	Cervical
	P1175fs5; Q766fs67	Endometrial (endometrioid)
	Q372fs*19	Ovarian (clear cell)
	R727fs*84	Ovarian (clear cell)
	W2049*	Colorectal
	P224fs*8	Gastric
	Y2254*	Cervical (clear cell)
	S1171fs*22	Duodenal
	ARID1A truncation	Lung
	P146fs*86	Pancreas
	K1072fs*21-subclonal	Endometrial (endometrioid)
Relapsed disease	Q1409; S1609fs38	Endometrial (endometrioid)
	Q1519fs8; G623fs6	Endometrial (endometrioid)
	Q372fs*19	Endometrial
	Q567*	Ovarian (clear cell)
	W1073fs*32	Breast
	Y447*	Cervical
	Y788*	Ovarian (high grade)
	F2141fs59, M1564fs1	Endometrial (endometrioid)
Blood	ARID1A-ARHGEF40 truncation	Hepatocellular
	Q1327fs*11	Colorectal
	Q1579*	Breast
	Q754*	Lung

PTAR1: prenyltransferase alpha subunit repeat containing 1; ARHGEF40: Rho guanine nucleotide exchange factors gene 40

Declarations

Author contributions

RF: Conceptualization, Formal analysis, Data curation, Writing—review & editing. GD: Conceptualization, Supervision. MF and PL: Data curation. VA and FPS: Formal analysis. GS: Supervision. All authors read and approved the submitted version.

Conflicts of interest

RF, MF, PL, VA, and FPS declare that they have no conflicts of interest. GS has served on advisory boards for TESARO Bio Italy S.r.l, Johnson & Johnson, Clovis Oncology Italy S.r.l. He received support for travel or accommodation from MSD Italy S.r.l and Clovis Oncology Italy S.r.l. GD has served on advisory board of Beigene and received support for travel and accommodation from Roche.

Ethical approval

The study complies with the declaration of Helsinki and was approved by the Ethics Committee of Fondazione Policlinico Universitario A. Gemelli IRCCS (ID5261).

Consent to participate

Informed consent to participate in the study was obtained from all participants.

Consent to publication

Not applicable.

Availability of data and materials

The data generated in the present study can be requested from the corresponding author (Gennaro Daniele, gennaro.daniele@policlinicogemelli.it).

Funding

Not applicable.

Copyright

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