Table Info

Table 2.

Tissue used for NGS analysis in ARID1A⁺ cancers and the most frequent concurrent alterations

Tissue for NGS	*PIK3CA*	*TP53*	*PTEN*	*CTNNB1*	*MLL2*
Peritoneum	H1047R; R93Q	-	G165E	-	-
Blood	-	-	E157fs*2	CTNNB1-CTNNB1 deletion	-
Cervix	R93W	R175C	-	-	-
Colon	-	R342*	-	-	-
Lymph node	E545A	-	G132V	S37C	-
Peritoneum	-	K164E	-	-	-
Uterus	-	-	R130G	-	-
Lymph node	-	-	Y27C; R130G	S33P	G1235fs*95
Blood	Splice site 1851-1G>A	-	-	-	P565fs*365
Blood	-	E349*; V216M	-	-	-
Uterus	R38H	R156C	Q87; D268fs30	-	-
Ovary	-	R273H	-	-	Q33370fs*22
Cervix	-	I195_L201>M	-	-	-
Peritoneum	-	D281E	-	-	-
Ovary	-	-	-	G34V	-
Colon	E542K; N1044Y	-	-	-	-
Ovary	E542K	-	-	-	-
Stomach	H1047R	K382fs*40	-	-	-
Breast	E365K; E453K	-	-	-	G3465fs37; A2205fs59
Duodenum	-	R248W	-	-	-
Soft tissue-bone	-	-	-	-	-
Pancreas	R108H	-	-	N387Y	P2354fs*30
Lymph node	R108H; R88Q	P152L; V73fs*50	R130G	-	-
Uterus	H1047R	P301fs*44	R130G; splice site 634+5G>A	-	-

-: none

Declarations

Author contributions

RF: Conceptualization, Formal analysis, Data curation, Writing—review & editing. GD: Conceptualization, Supervision. MF and PL: Data curation. VA and FPS: Formal analysis. GS: Supervision. All authors read and approved the submitted version.

Conflicts of interest

RF, MF, PL, VA, and FPS declare that they have no conflicts of interest. GS has served on advisory boards for TESARO Bio Italy S.r.l, Johnson & Johnson, Clovis Oncology Italy S.r.l. He received support for travel or accommodation from MSD Italy S.r.l and Clovis Oncology Italy S.r.l. GD has served on advisory board of Beigene and received support for travel and accommodation from Roche.

Ethical approval

The study complies with the declaration of Helsinki and was approved by the Ethics Committee of Fondazione Policlinico Universitario A. Gemelli IRCCS (ID5261).

Consent to participate

Informed consent to participate in the study was obtained from all participants.

Consent to publication

Not applicable.

Availability of data and materials

The data generated in the present study can be requested from the corresponding author (Gennaro Daniele, gennaro.daniele@policlinicogemelli.it).

Funding

Not applicable.

Copyright

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