Mechanisms of action for components of PCV
| Medication | Mechanism of action |
|---|---|
| Procarbazine hydrochloride | Possible mechanism is through the inhibition of trans-methylation of methionine into transfer-RNA (t-RNA) thus inhibiting protein synthesis [25] |
| Lomustine | Nitrosourea that works as an alkylating agent [9] |
| Vincristine sulfate | Inhibits the formation of microtubules by binding to tubulin which leads to mitosis arrest. It also is able to block glutamic acid utilization and thereby interfere with the synthesis of nucleic acids and proteins [26] |
BLW: Conceptualization, Supervision, Writing—review & editing. MM: Conceptualization, Project administration, Visualization. MS, AS and MM: Writing—original draft, Writing—review & editing
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© The Author(s) 2023.