Table Info

Table 1.

FDA-approved alkylating agents for the treatment of brain tumors

Medication	Tumor type	Mechanism of action	Reference
Temozolomide	GBM and anaplastic astrocytoma	Alkylating agent that leads to methylation and later apoptosis of impacted cells	[6]
Carmustine	Glial tumors (wafers are frequently placed at the time of GBM resection as a bridge to radiation therapy)	Alkylating agent administered via intravenous injection or local implantation in wafer form	[7]
Lomustine	Glial and non-glial cell tumors like medulloblastoma	Nitrosourea works as an alkylating agent	[8, 9]

Declarations

Author contributions

BLW: Conceptualization, Supervision, Writing—review & editing. MM: Conceptualization, Project administration, Visualization. MS, AS and MM: Writing—original draft, Writing—review & editing

Conflicts of interest

The views expressed in this article are those of the authors and do not necessarily reflect the official policy or position of the Uniformed Services University of the Health Sciences, the Department of Defense, or the U.S. Government.

Ethical approval

Not applicable.

Consent to participate

Not applicable.

Consent to publication

Not applicable.

Availability of data and materials

Not applicable.

Funding

Not applicable.

Copyright

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