Table Info

Table 1.

A comprehensive list of ongoing oncology clinical trials involving IFNγ and IL-12, either alone or in combination with other cytokine-based therapies

Cytokine	Clinical trial ID	Phase	Number of patients	Cancer type	Treatment	Status	Estimated study completion date
IFNγ	NCT03112590	I/II	51	HER2⁺ breast cancer	IFNγ plus paclitaxel, trastuzumab and pertuzumab	Active	June 2023
IFNγ	NCT03063632	II	28	Mycosis fungoides, Sezary syndrome, and advanced synovial sarcoma	IFNγ plus pertuzumab	Active	April 2023
IFNγ	NCT05268172	I	40	Malignant pleural effusion tumours	IFNγ plus T cells	Recruiting	December 2023
IFNγ	NCT03747484	I/II	16	Metastatic or unresectable Merkel cell cancer	IFNγ plus T cells and avelumab or pembrolizumab	Recruiting	December 2025
IL-12	NCT02555397	I	15	Prostate cancer	Adenovirus-mediated cytotoxic and IL-12 gene therapy	Active	February 2023
IL-12	NCT04491955	II	23	Small bowel cancer and CRC	NHS-IL-12 plus CV301 vaccine, M7824 (anti-PD-L1/TGFβ Trap fusion protein) and N-803 (IL-15 superagonist) combination immunotherapy	Active	July 2024
IL-12	NCT03439085	II	77	HPV associated malignancies	DNA plasmid-encoding IL-12/HPV DNA plasmids vaccine (MEDI0457) plus durvalumab	Active	December 2022
IL-12	NCT04015700	I	9	Glioblastoma	Plasmid encoded IL-12 with personalised neoantigen DNA vaccine	Active	April 2023
IL-12	NCT04911166	I	16	Metastatic non-small cell lung cancer	Adenovirus-mediated IL-12 gene therapy plus atezolimumab	Recruiting	June 2024
IL-12	NCT05162118	I/II	51	Advanced pancreatic cancer	VG161 (IL-12/IL-15/PD-L1 blocking peptide) oncolytic HSV1 injection plus nivolumab	Recruiting	December 2025
IL-12	NCT04287868	I/II	51	Advanced HPV-associated malignancies	NHS-IL-12 plus PDS0101 and M7824 (anti-PD-L1/TGFβ Trap fusion protein)	Recruiting	January 2024
IL-12	NCT05392699	I	60	Advanced solid tumours	Human IL-12 mRNA	Recruiting	January 2027
IL-12	NCT04806464	I	44	Primary liver cancer	IL-12/IL-15/PD-L1 blocking peptide oncolytic HSV1 injection	Recruiting	December 2022
IL-12	NCT04708470	I/II	90	HPV-associated malignancies, small bowel cancer, and CRC	NHS-IL-12 plus bintrafusp alfa and entinostat	Recruiting	December 2024
IL-12	NCT04471987	I	94	Advanced or metastatic solid tumours	IL-12-L19L19	Recruiting	December 2023
IL-12	NCT04388033	I/II	10	Glioblastoma	IL-12 plus DC tumour vaccine and temozolomide	Recruiting	December 2023
IL-12	NCT02483312	I	9	Acute myeloid leukemia	IL-12	Recruiting	February 2022
IL-12	NCT04758897	I	18	Advanced malignant solid tumours	VG161 (IL-12/IL-15/PD-L1 blocking peptide) oncolytic HSV1 injection	Recruiting	December 2022
IL-12	NCT05477849	I	30	Advanced malignant solid tumours	IL-12/IL-15 dual-regulated oncolytic HSV1 injection	Recruiting	December 2024
IL-12	NCT04303117	I/II	64	Kaposi sarcoma	NHS-IL-12 with or without M7824 (anti-PD-L1/TGFβ Trap fusion protein)	Recruiting	December 2025
IL-12	NCT05717712	I	18	Glioma	Adenovirus-mediated-non-secretory-IL-12	Recruiting	January 2028

HER2: human epidermal growth factor receptor 2; TGFβ: transforming growth factor β; HPV: human papillomavirus; HSV1: herpes simplex virus 1; mRNA: messenger RNA

Declarations

Author contributions

EJ: Conceptualization, Methodology, Writing—original draft, Writing—review & editing.

Conflicts of interest

The author declares that he has no conflicts of interest.

Ethical approval

Not applicable.

Consent to participate

Not applicable.

Consent to publication

Not applicable.

Availability of materials and data

Not applicable.

Funding

Not applicable.

Copyright

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