Selected in vivo anticancer effects of SAB
| Type of cancer | Mouse/mice/hamster model | Morphological effects | Mechanism(s) of action | References |
|---|---|---|---|---|
| Breast cancer | Mouse model | Apoptosis induction, reduction of oxidative stress, anti-inflammatory, anti-angiogenesis | ↓MMp-8, ↓TNF, ↓COX-2, ↓p53, ↑caspase 3 | [83] |
| Mouse model | Increased cell apoptosis, inhibition of growth | ↓PCNA, ↓Survivin, ↓BCL-XL | [84] | |
| Colon cancer | LoVo cells HCT-116 cells nude mice | Inhibits tumor growth, inhibits tumor invasion, multidrug resistance | ↓CD44, ↓CD133, ↓SOX-2, ↓ABCG2 | [108] |
| BALB/c nude mice injected with HCT116 cells | Pro-death autophagy | ↑Atg5 expression, ┴AKT/mTOR signaling pathway, ↓p70S6K | [63] | |
| Glioma | U87 xenograft nude mice | Tumor volume reduced, weight reduced, increases ROS | ↑p38, ↑p53 | [111] |
| Oral cancer | Hamster | Antiproliferative, inhibition of angiogenesis | ↓HIF-1α, ↓VEGF | [122, 123] |
| Head and neck cancer | JHU-013 xenograft mouse | Apoptosis, anti-proliferative, angiogenesis | ↓COX-2 | [57, 58] |
↑ increase expression, ↓ decrease expression, ┴ inhibit
This manuscript has been written by IS, ZA and SB. It was edited by BM, ASN and RM. All authors have read and agreed to the published version of the manuscript.
The authors declare that there are no conflicts of interest.
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This work was supported by Higher Education Commission of Pakistan (HEC) grant. The funder had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.
© The Author(s) 2020.