Table Info

Table 2.

Selected in vivo anticancer effects of SAB

Type of cancer	Mouse/mice/hamster model	Morphological effects	Mechanism(s) of action	References
Breast cancer	Mouse model	Apoptosis induction, reduction of oxidative stress, anti-inflammatory, anti-angiogenesis	↓MMp-8, ↓TNF, ↓COX-2, ↓p53, ↑caspase 3	[83]
Breast cancer	Mouse model	Increased cell apoptosis, inhibition of growth	↓PCNA, ↓Survivin, ↓BCL-XL	[84]
Colon cancer	LoVo cells HCT-116 cells nude mice	Inhibits tumor growth, inhibits tumor invasion, multidrug resistance	↓CD44, ↓CD133, ↓SOX-2, ↓ABCG2	[108]
Colon cancer	BALB/c nude mice injected with HCT116 cells	Pro-death autophagy	↑Atg5 expression, ┴AKT/mTOR signaling pathway, ↓p70S6K	[63]
Glioma	U87 xenograft nude mice	Tumor volume reduced, weight reduced, increases ROS	↑p38, ↑p53	[111]
Oral cancer	Hamster	Antiproliferative, inhibition of angiogenesis	↓HIF-1α, ↓VEGF	[122, 123]
Head and neck cancer	JHU-013 xenograft mouse	Apoptosis, anti-proliferative, angiogenesis	↓COX-2	[57, 58]

↑ increase expression, ↓ decrease expression, ┴ inhibit

Declarations

Author contributions

This manuscript has been written by IS, ZA and SB. It was edited by BM, ASN and RM. All authors have read and agreed to the published version of the manuscript.

Conflicts of interest

The authors declare that there are no conflicts of interest.

Ethical approval

Not applicable.

Consent to participate

Not applicable.

Consent to publication

Not applicable.

Availability of data and materials

Not applicable.

Funding

This work was supported by Higher Education Commission of Pakistan (HEC) grant. The funder had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.

Copyright

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