Selected anticancer effects of SAB on tumor cell lines
| Type of cancer | Model/cell line | Morphological effects | Mechanisms of action | References |
|---|---|---|---|---|
| Oral cancer | CAL27, SCC4, Leuk1 | Apoptosis, inhibits cell growth, anti-angiogenesis | ↓HIF-1α, ↓TNFα, ↓MMP9, ↓Tenascin-C, ↓Osteopontin, ↓TGFβ, ↓Cox-2, ↓HGF, ↓MMP2, ↑THBS2 | [75, 76] |
| CAL27, HN4, and Leuk1 | Apoptosis, inhibits cell growth, modulates Warburg effect | ↓MMP, ↓PI3K/Akt/HIF-α | [123] | |
| Leukemia | HL-60 | Apoptosis, inhibits cell growth | - | [125] |
| Cervical cancer | Hela cells SAB + ATO | Apoptosis, inhibits cell growth | ↓pro-caspase 3, ↑PARP cleavage | [96] |
| Retinoblastoma | HXO-RB44 | Apoptosis, cell volume shrinkage, chromatics agglutination, inhibits cell growth, cell cycle arrest at S phase | ↑caspase 3 | [117] |
↑ increases expression, ↓ decreases expression
This manuscript has been written by IS, ZA and SB. It was edited by BM, ASN and RM. All authors have read and agreed to the published version of the manuscript.
The authors declare that there are no conflicts of interest.
Not applicable.
Not applicable.
Not applicable.
Not applicable.
This work was supported by Higher Education Commission of Pakistan (HEC) grant. The funder had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.
© The Author(s) 2020.