Table Info

Table 1.

Biological evaluation of Syzygium aqueum (Burm.f.) Alston against several cancer cell lines

N	Parts of the plant	Solvents	Concentration	Type of cancer	Major finding	Reference
1	Stem bark (oleanolic acid and b-sitosterol)	Methanol	100 μL	Cervical, breast	It was found compound one to be significant against the tested cell line while compound 2 was only on HeLa cell line	[30]
2	Leaves (essential oils)	Dimethyl sulphoxide	1%	Breast	As measured by an IC₅₀ value of 76.40 μg/mL, it exhibited modest activity against the MCF-7 cell line	[31]
3	Stem bark	Methanol	1.5625–100 μg/mL	Cervical, breast, lung	The IC₅₀ values for alphitolic acid were 16.12 mg/mL and 7.37 mg/mL, indicating that it was toxic to the HeLa and T47D cell lines. A549 cells were inhibited to a modest degree (IC₅₀ = 84.41 μg/mL), nevertheless. Arjunolic acid was also discovered to be toxic to HeLa cell lines, having an IC₅₀ of 6.74 μg/mL	[28]
4	Fruits	Aqueous, methanol	-	Breast cancer cell line	Aqueous extracts revealed antiproliferation effects on MCF-7 cell lines (P < 0.05) after 72 h, however, the effects were insignificant on a non-cancer-origin cell line and were not seen in the 24-h or 48-h time periods	[29]
5	Leaves	Methanol	0.01, 0.1, 1, 10, and 100 μg/mL	Breast	At 100 μg/mL, Syzygium aqueum was observed to significantly (P < 0.05) boost MCF-7 cell growth	[32]
6	Stem bark	Methanol	100 μL	Cervical, breast cancer	Butyrospermol was only moderately cytotoxic (43.59 μg/mL) against the HeLa cell line and barely cytotoxic at all against the T45D and A549 cell lines. And when tested with the 2,3-bis [2-methyloxy-4-nitro-5-sulfophenyl]-2H-tetrazolium-5-carboxanilide (XTT) assay, sitosterone (29.96 μg/mL) exhibited considerable toxicity towards the A549 cell line	[33]
7	-	-	50 μg/mL and 100 μg/mL	Fibroblasts, breast	In addition, neither the ethanolic nor the aqueous extracts showed any antiproliferative effects on 4T1 or 3T3 cells at 50 μg/mL or 100 μg/mL	[34]

-: not applicable

Declarations

Author contributions

MDA: Conceptualization, Writing—original draft, Writing—review & editing. HAH: Writing—review & editing, Data curation.

Conflicts of interest

The authors declare that they have no conflicts of interest.

Ethical approval

Not applicable.

Consent to participate

Not applicable.

Consent to publication

Not applicable.

Availability of data and materials

Not applicable.

Funding

Not applicable.

Copyright

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