Exploration of Targeted Anti-tumor Therapy

Table 1. Clinical and pathological characteristics of included rectal cancer patients

Characteristics	Surviving > five years (%) n = 33	Surviving < five years (%) n = 20	Chi-squared test	P-value
Sex			0.37	0.54
Male	19 (57)	9 (45)
Female	14 (43)	11 (55)
Age (years)			0.55	0.46
< 70	15 (45)	12 (60)
≥ 70	18 (55)	8 (40)
Tumor location (cm)	6 (2–14)	4 (1–17)	198.5	< 0.05
Operation type			0.45	0.5
Anterior resection	16 (48)	7 (35)
Abdominoperineal resection	17 (52)	13 (65)
pTNM stage			*	< 0.05
I	14 (42)	0 (0)
II	13 (39)	2 (10)
III	6 (18)	15 (75)
IV	0 (0)	3 (15)
Local recurrence			7.28	< 0.05
No	31 (94)	12 (60)
Yes	2 (6)	8 (40)
Distal recurrence			21.6	< 0.05
No	29 (88)	4 (20)
Yes	4 (12)	16 (80)

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*: Fisher’s exact test; pTNM: pathological tumor, node, and metastasis

Declarations

Author contributions

TDP and XFS: Conceptualization. TDP: Methodology. TDP: Software. TDP, VR, BL, CF, and XFS: Formal analysis. BL and CF: Data curation. TDP: Writing—original draft. TDP, VR, BL, CF, and XFS: Writing—review & editing.

Conflicts of interest

The authors declare that there are no conflicts of interest.

Ethical approval

The ethical applications were approved by the Institutional Ethics Committee of Linköping University (Dnr 2012-107-31 and Dnr 2014-79-31).

Consent to participate

The informed consent to participate in the study was obtained from all participants.

Consent to publication

Not applicable.

Availability of data and materials

The IHC image data used in this study are available at the first author’s homepage: https://sites.google.com/view/tuan-d-pham/codes under the name “Rectal cancer biopsy”.

Funding

Not applicable.

Copyright

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