Immunotherapies for glioblastoma

Serial No.Immune therapiesObservationsReferences
1DCVaxHigher levels of tumor-associated antigens on GBM cells or a GBM stem cell population were linked to prolonged overall survival and progression-free survival[96]
2PD-1 antibodyTreatment of malignancies melanoma, is used to block the immunological checkpoint. Immune checkpoint blockade, in contrast to employing CTL to fight cancer, shuts down the immune response in a way that allows depleted CTL to attack cancer[97]
3MAbs (bevacizumab)Block tumor blood vessels from growing and are also used for the treatment of a variety of cancers, including GBM[102]
4NCAMsOverexpression of NK-1R in glioma tumors has led to the development of NK-1R-targeted therapies for the treatment of glioma tumors[99]