Selected anti-cancer effects of Tan compounds in-vitro
Cancer type | Cell line | Pathways/molecules altered | References |
---|---|---|---|
Astrocytoma | Astrocytoma cells | ↑Notch-1 | [97] |
Breast cancer | MDA-MB-231, MCF-7 | ↓HIF-1α, ↓VEGF | [102] [16] |
Bladder cancer | BCa | ↓EMT | [15] |
Cervical cancer | HPV positive CaSki | ↓E6 and E7, ↑p53 | [19] |
↓CYP2J2-mediated astemizole O-demethylation | [19] [117] | ||
Cervix carcinoma | Stemness-like cancer cells | ↓YAP mRNAs | [98] |
Colon cancer | SW480 | ↑E-cadherin, ↓vimentin and MMP-9 | [118] |
CRC | ↓AMPK, ↑Skp2 | [52] | |
Esophageal cancer | EC-109 | ↑caspase-4, ↑CHO | [24] |
Gastric cancer | AGS | ↓EGFR, ↓IGFR, ↓PI3K, ↓AKT, ↓mTOR, ↓NF-κB-p65, ↓COX-2 and MMP-2, -7 and -9 S, ↑p-p38, ↑p-JNK, ↑p53, ↑p21, ↑caspase-3 and caspase-8, ↑PARP↓VEGFR, ↓HER2, ↓Ras, ↓Raf, ↓MEK, ↓ERK | [119] [58] |
Gastric cancer | SGC-7901 | ↓Ki-67, ↓PCAN, ↓MMP-2, ↓MMP-9, ↓FOXM1, ↑P21 | [69] |
SNU-638 & MKN1 | ↑Bcl-2, ↓caspase-3, ↓p-STAT3 | [54] [37] | |
Glioma | U251 | ↓p-PI3K, ↓Bcl-2, ↓p-Akt, ↑Bax, ↑LC3B, ↑Beclin 1 | [37] |
Leukaemia | APL | C/EBPβ | [99] |
Liver cancer | HepG2 | ↓CYP2J2 activity | [117] |
HepG2 | ↑LDLR, ↑p53, ↓HNF-1α, ↓Nec-1, ↓PCSK9 | [53] [81] | |
Lung cancer | A549 | ↑Cleaved Caspase-3 and Bax, ↓VEGF, ↓VEGFR2, ↓p-PI3K, ↓p-Akt, ↓Bcl-2, ↓Caspase-3 protein | [25] [26] [30] [31] |
Melanoma | A375 | ↑Beclin-1, ↑LC3-II expression, ↓pPI3K, ↓p-AKT, ↓p-mTOR, ↓p-p7036k1 | [41] |
Oral cancer | SCC-9 squamous carcinoma | ↑ROS, ↑Beclin 1, ↑Atg5 | [89] [90] |
Ovarian cancer | TOV-21G | ↑TRAIL-induced apoptosis, ↑DR5, ↑ROS-JNK-CHOP, ↑miR-205, ↑Bcl-2 ↓Mcl-1L, ↓PI3K, ↓AKT, ↓JNK | [43] [45] |
Osteosarcoma | 143B | ↓Ki67, ↓PCNA | [42] |
MG-63 | ↑Cleaved-PARP, ↑ROS, ↑Caspase-3, -8 and -9 | [96] | |
PC | PC-3 | ↓Beclin1, ↓LC3-II | [32] |
LNCaP | ↑maspin, ↑ARs | [120] | |
PC12 | ↓p-Akt, ↓p-ERK1/2, ↑p-FOXO3a, ↑c-Raf | [121] |
EMT: epithelial-mesenchymal transition; FoxM1: forkhead box M1; MMP-2: matrix metalloproteinase 2; MMP-9: matrix metalloproteinase 9
This manuscript is written by IN, SR, MM, and SS. It was edited by MRK, ASN, and KSA. All authors have read and agreed to the published version of the manuscript.
The authors declare that they have no conflicts of interest.
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This work was supported by Higher Education Commission of Pakistan (HEC) grant and National Research Foundation of Korea (NRF) grant funded by the Korean government (MSIP) (NRF-2018R1D1A1B07042969). The funding agencies have no role in the study design; in the collection, analysis and interpretation of the data; in the writing of the report; and in the decision to submit the paper for publication.
© The Author(s) 2020.