Exploration of Targeted Anti-tumor Therapy

Figure 2. Flow chart for the management of patients with advanced/metastatic urothelial cancer. * Combination therapy eligibility: ECOG PS 0-2, GFR ≥ 30 ml/min, adequate organ functions; # Rechallenge with platinum/Gem if progression occurred ≥ 12 months after the end of previous platinum-based CT or ≥ 12 months after the end of previous platinum-based CT and maintenance avelumab. Alt: alterations; Ave: avelumab; BSC: best supportive care; CT: chemotherapy; EV: enfortumab vedotin; FGFR: fibroblast growth factor receptor; Gem: gemcitabine; ICI: immune checkpoint inhibitor; PD: progression disease; PD-L1: programmed cell death ligand-1; SG: sacituzumab govitecan; T-DXd: trastuzumab deruxtecan; ECOG PS: Eastern Cooperative Oncology Group Performance Status. This image was created using Canva, https://www.canva.com/

Declarations

Author contributions

IT, GCG, and UV: Conceptualization, Investigation, Writing—original draft, Writing—review & editing. UV, FT, and GS: Validation, Writing—review & editing, Supervision. SM, LT, and MP: Writing—review & editing. All authors read and approved the submitted version.

Conflicts of interest

Ursula Vogl received grant from Fond’Action; received institutional personal honoraria from Pfizer, Astellas, Janssen, Merck, MSD, BMS, Ipsen, Healthbook, Novartis AAA, Bayer, Grasso consulting, Vaccentis; received private personal honoraria from Healthbook, SAMO, Inselspital Bern, Kantonsspital Chur, Kantonsspital Baden, Ipsen; and received travel grant from Astra Zeneca and Janssen. Fabio Turco received travel grant from Bayer. All other authors declare the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

Ethical approval

Not applicable.

Consent to participate

Not applicable.

Consent to publication

Not applicable.

Availability of data and materials

Not applicable.

Funding

Not applicable.

Copyright

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