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References
Tommasi L, Laeng B. Psychology of spatial cognition.Wiley Interdiscip Rev Cogn Sci. 2012;3:565–80. [DOI] [PubMed]
van Asselen M, Kessels RP, Kappelle LJ, Postma A. Categorical and coordinate spatial representations within object-location memory.Cortex. 2008;44:249–56. [DOI] [PubMed]
Epstein RA, Patai EZ, Julian JB, Spiers HJ. The cognitive map in humans: spatial navigation and beyond.Nat Neurosci. 2017;20:1504–13. [DOI] [PubMed] [PMC]
Silva A, Martínez MC. Spatial memory deficits in Alzheimer’s disease and their connection to cognitive maps’ formation by place cells and grid cells.Front Behav Neurosci. 2023;16:1082158. [DOI] [PubMed] [PMC]
Fernandez-Baizan C, Paula Fernandez Garcia M, Diaz-Caceres E, Menendez-Gonzalez M, Arias JL, Mendez M. Patients with Parkinson's Disease Show Alteration in their Visuospatial Abilities and in their Egocentric and Allocentric Spatial Orientation Measured by Card Placing Tests.J Parkinsons Dis. 2020;10:1807–16. [DOI] [PubMed]
Hort J, Laczó J, Vyhnálek M, Bojar M, Bures J, Vlcek K. Spatial navigation deficit in amnestic mild cognitive impairment.Proc Natl Acad Sci U S A. 2007;104:4042–7. [DOI] [PubMed] [PMC]
Kozhevnikov M, Hegarty M. A dissociation between object manipulation spatial ability and spatial orientation ability.Mem Cognit. 2001;29:745–56. [DOI] [PubMed]
Hegarty M, Richardson AE, Montello DR, Lovelace K, Subbiah I. Development of a self-report measure of environmental spatial ability.Intelligence. 2002;30:425–47. [DOI]
Tuena C, Mancuso V, Stramba-Badiale C, Pedroli E, Stramba-Badiale M, Riva G, et al. Egocentric and Allocentric Spatial Memory in Mild Cognitive Impairment with Real-World and Virtual Navigation Tasks: A Systematic Review.J Alzheimers Dis. 2021;79:95–116. [DOI] [PubMed] [PMC]
Schöberl F, Zwergal A, Brandt T. Testing Navigation in Real Space: Contributions to Understanding the Physiology and Pathology of Human Navigation Control.Front Neural Circuits. 2020;14:6. [DOI] [PubMed] [PMC]
Fernandez-Baizan C, Arias JL, Mendez M. Spatial memory assessment reveals age-related differences in egocentric and allocentric memory performance.Behav Brain Res. 2020;388:112646. [DOI] [PubMed]
Laczó J, Andel R, Vyhnalek M, Vlcek K, Magerova H, Varjassyova A, et al. Human analogue of the morris water maze for testing subjects at risk of Alzheimer's disease.Neurodegener Dis. 2010;7:148–52. [DOI] [PubMed]
Cogné M, Taillade M, N’Kaoua B, Tarruella A, Klinger E, Larrue F, et al. The contribution of virtual reality to the diagnosis of spatial navigation disorders and to the study of the role of navigational aids: A systematic literature review.Ann Phys Rehabil Med. 2017;60:164–76. [DOI] [PubMed]
Diersch N, Wolbers T. The potential of virtual reality for spatial navigation research across the adult lifespan.J Exp Biol. 2019;222:jeb187252. [DOI] [PubMed]
Munoz-Montoya F, Fidalgo C, Juan MC, Mendez-Lopez M. Memory for Object Location in Augmented Reality: The Role of Gender and the Relationship Among Spatial and Anxiety Outcomes.Front Hum Neurosci. 2019;13:113. [DOI] [PubMed] [PMC]
Ponce D, Mendez-Lopez M, Lluch J, Juan MC. Extended Reality to Assess Short-Term Spatial Memory-A Comparative Study of Mixed Reality, Augmented Reality, and Virtual Reality.Sensors (Basel). 2024;24:7938. [DOI] [PubMed] [PMC]
Iachini T. Spatial memory and frames of reference: How deeply do we rely on the body and the environment?Cogn Process. 2024;25:79–83. [DOI] [PubMed] [PMC]
Orti R, Coello Y, Iachini T, Ruggiero G. Switching between body and environment: the selective effect of spatial misalignment.J Environ Psychol. 2023;85:101944. [DOI]
Ruotolo F, van der Ham I, Postma A, Ruggiero G, Iachini T. How coordinate and categorical spatial relations combine with egocentric and allocentric reference frames in a motor task: effects of delay and stimuli characteristics.Behav Brain Res. 2015;284:167–78. [DOI] [PubMed]
Ruotolo F, Iachini T, Ruggiero G, van der Ham IJ, Postma A. Frames of reference and categorical/coordinate spatial relations in a “what was where” task.Exp Brain Res. 2016;234:2687–96. [DOI] [PubMed] [PMC]
Ruggiero G, Frassinetti F, Iavarone A, Iachini T. The lost ability to find the way: topographical disorientation after a left brain lesion.Neuropsychology. 2014;28:147–60. [DOI] [PubMed]
Ekstrom AD, Spiers HJ, Bohbot VD, Rosenbaum RS. Human Spatial Navigation. New Jersey, US: Princeton University Press; 2018.
Colgin LL, Moser EI, Moser MB. Understanding memory through hippocampal remapping.Trends Neurosci. 2008;31:469–77. [DOI] [PubMed]
Piccardi L, Nori R, Cimadevilla JM, Kozhevnikov M. The Contribution of Internal and External Factors to Human Spatial Navigation.Brain Sci. 2024;14:585. [DOI] [PubMed] [PMC]
Hartley T, Lever C, Burgess N, O’Keefe J. Space in the brain: how the hippocampal formation supports spatial cognition.Philos Trans R Soc Lond B Biol Sci. 2013;369:20120510. [DOI] [PubMed] [PMC]
Burgess N. Spatial cognition and the brain.Ann N Y Acad Sci. 2008;1124:77–97. [DOI] [PubMed]
Doeller CF, King JA, Burgess N. Parallel striatal and hippocampal systems for landmarks and boundaries in spatial memory.Proc Natl Acad Sci U S A. 2008;105:5915–20. [DOI] [PubMed] [PMC]
Burgess N, O’Keefe J. Neural representations in human spatial memory.Trends Cogn Sci. 2003;7:517–9. [DOI] [PubMed]
Dong LL, Fiete IR. Grid Cells in Cognition: Mechanisms and Function.Annu Rev Neurosci. 2024;47:345–68. [DOI] [PubMed]
Taube JS. The Discovery of Head Direction Cells: A Personal Account.Hippocampus. 2025;35:e23670. [DOI] [PubMed]
Long X, Bush D, Deng B, Burgess N, Zhang SJ. Allocentric and egocentric spatial representations coexist in rodent medial entorhinal cortex.Nat Commun. 2025;16:356. [DOI] [PubMed] [PMC]
Poulter S, Lee SA, Dachtler J, Wills TJ, Lever C. Vector trace cells in the subiculum of the hippocampal formation.Nat Neurosci. 2021;24:266–75. [DOI] [PubMed] [PMC]
Green J, Bruno CA, Traunmüller L, Ding J, Hrvatin S, Wilson DE, et al. A cell-type-specific error-correction signal in the posterior parietal cortex.Nature. 2023;620:366–73. [DOI] [PubMed] [PMC]
Cavanna AE, Trimble MR. The precuneus: a review of its functional anatomy and behavioural correlates.Brain. 2006;129:564–83. [DOI] [PubMed]
Czajkowski R, Jayaprakash B, Wiltgen B, Rogerson T, Guzman-Karlsson MC, Barth AL, et al. Encoding and storage of spatial information in the retrosplenial cortex.Proc Natl Acad Sci U S A. 2014;111:8661–6. [DOI] [PubMed] [PMC]
Rolls ET. Spatial coordinate transforms linking the allocentric hippocampal and egocentric parietal primate brain systems for memory, action in space, and navigation.Hippocampus. 2020;30:332–53. [DOI] [PubMed]
Byrne P, Becker S, Burgess N. Remembering the past and imagining the future: a neural model of spatial memory and imagery.Psychol Rev. 2007;114:340–75. [DOI] [PubMed] [PMC]
Clark BJ, Simmons CM, Berkowitz LE, Wilber AA. The retrosplenial-parietal network and reference frame coordination for spatial navigation.Behav Neurosci. 2018;132:416–29. [DOI] [PubMed] [PMC]
Hok V, Chah E, Save E, Poucet B. Prefrontal cortex focally modulates hippocampal place cell firing patterns.J Neurosci. 2013;33:3443–51. [DOI] [PubMed] [PMC]
Humphries MD, Prescott TJ. The ventral basal ganglia, a selection mechanism at the crossroads of space, strategy, and reward.Prog Neurobiol. 2010;90:385–417. [DOI] [PubMed]
Nedelska Z, Andel R, Laczó J, Vlcek K, Horinek D, Lisy J, et al. Spatial navigation impairment is proportional to right hippocampal volume.Proc Natl Acad Sci U S A. 2012;109:2590–4. [DOI] [PubMed] [PMC]
Iglói K, Doeller CF, Berthoz A, Rondi-Reig L, Burgess N. Lateralized human hippocampal activity predicts navigation based on sequence or place memory.Proc Natl Acad Sci U S A. 2010;107:14466–71. [DOI] [PubMed] [PMC]
Katsuki F, Constantinidis C. Unique and shared roles of the posterior parietal and dorsolateral prefrontal cortex in cognitive functions.Front Integr Neurosci. 2012;6:17. [DOI] [PubMed] [PMC]
Farovik A, Place RJ, McKenzie S, Porter B, Munro CE, Eichenbaum H. Orbitofrontal cortex encodes memories within value-based schemas and represents contexts that guide memory retrieval.J Neurosci. 2015;35:8333–44. [DOI] [PubMed] [PMC]
Alexander AS, Tung JC, Chapman GW, Conner AM, Shelley LE, Hasselmo ME, et al. Adaptive integration of self-motion and goals in posterior parietal cortex.Cell Rep. 2022;38:110504. [DOI] [PubMed] [PMC]
Blondiaux E, Diamantaras A, Schumacher R, Blanke O, Müri R, Heydrich L. The neural correlates of topographical disorientation-a lesion analysis study.Ann Clin Transl Neurol. 2024;11:520–4. [DOI] [PubMed] [PMC]
Chersi F, Burgess N. The Cognitive Architecture of Spatial Navigation: Hippocampal and Striatal Contributions.Neuron. 2015;88:64–77. [DOI] [PubMed]
Uc EY, Rizzo M, Anderson SW, Sparks JD, Rodnitzky RL, Dawson JD. Impaired navigation in drivers with Parkinson’s disease.Brain. 2007;130:2433–40. [DOI] [PubMed]
Glikmann-Johnston Y, Fink KD, Deng P, Torrest A, Stout JC. Spatial memory in Huntington's disease: A comparative review of human and animal data.Neurosci Biobehav Rev. 2019;98:194–207. [DOI] [PubMed]
Rondi-Reig L, Paradis AL, Lefort JM, Babayan BM, Tobin C. How the cerebellum may monitor sensory information for spatial representation.Front Syst Neurosci. 2014;8:205. [DOI] [PubMed] [PMC]
Hampstead BM, Stringer AY, Stilla RF, Amaraneni A, Sathian K. Where did I put that? Patients with amnestic mild cognitive impairment demonstrate widespread reductions in activity during the encoding of ecologically relevant object-location associations.Neuropsychologia. 2011;49:2349–61. [DOI] [PubMed] [PMC]
Kopelman MD, Stanhope N, Kingsley D. Temporal and spatial context memory in patients with focal frontal, temporal lobe, and diencephalic lesions.Neuropsychologia. 1997;35:1533–45. [DOI]
Sommer T, Rose M, Gläscher J, Wolbers T, Büchel C. Dissociable contributions within the medial temporal lobe to encoding of object-location associations.Learn Mem. 2005;12:343–51. [DOI] [PubMed] [PMC]
Castegnaro A, Howett D, Li A, Harding E, Chan D, Burgess N, et al. Assessing mild cognitive impairment using object-location memory in immersive virtual environments.Hippocampus. 2022;32:660–78. [DOI] [PubMed] [PMC]
Boone AP, Maghen B, Hegarty M. Instructions matter: Individual differences in navigation strategy and ability.Mem Cognit. 2019;47:1401–14. [DOI] [PubMed]
Saucier DM, Green SM, Leason J, MacFadden A, Bell S, Elias LJ. Are sex differences in navigation caused by sexually dimorphic strategies or by differences in the ability to use the strategies?Behav Neurosci. 2002;116:403–10. [DOI] [PubMed]
Keeley RJ, Tyndall AV, Scott GA, Saucier DM. Sex difference in cue strategy in a modified version of the Morris water task: correlations between brain and behaviour.PLoS One. 2013;8:e69727. [DOI] [PubMed] [PMC]
Siemens MN, Kelly DM. Sex differences and the effect of instruction on reorientation abilities by humans.Mem Cognit. 2018;46:566–76. [DOI] [PubMed]
Joue G, Navarro-Schröder T, Achtzehn J, Moffat S, Hennies N, Fuß J, et al. Effects of estrogen on spatial navigation and memory.Psychopharmacology (Berl). 2024;241:1037–63. [DOI] [PubMed] [PMC]
Voyer D, Postma A, Brake B, Imperato-McGinley J. Gender differences in object location memory: a meta-analysis.Psychon Bull Rev. 2007;14:23–38. [DOI] [PubMed]
De Goede M, Postma A. Gender differences in memory for objects and their locations: a study on automatic versus controlled encoding and retrieval contexts.Brain Cogn. 2008;66:232–42. [DOI] [PubMed]
Llana T, Mendez M, Juan MC, Mendez-Lopez M. Navigational object-location memory assessment in real and virtual environments: A systematic review.Behav Brain Res. 2025;480:115388. [DOI] [PubMed]
Verde P, Piccardi L, Bianchini F, Guariglia C, Carrozzo P, Morgagni F, et al. Gender differences in navigational memory: pilots vs. nonpilots.Aerosp Med Hum Perform. 2015;86:103–11. [DOI] [PubMed]
Ariel R, Moffat SD. Age-related similarities and differences in monitoring spatial cognition.Neuropsychol Dev Cogn B Aging Neuropsychol Cogn. 2018;25:351–77. [DOI] [PubMed] [PMC]
Cerman J, Andel R, Laczo J, Vyhnalek M, Nedelska Z, Mokrisova I, et al. Subjective Spatial Navigation Complaints - A Frequent Symptom Reported by Patients with Subjective Cognitive Decline, Mild Cognitive Impairment and Alzheimer’s Disease.Curr Alzheimer Res. 2018;15:219–28. [DOI] [PubMed]
Tu S, Spiers HJ, Hodges JR, Piguet O, Hornberger M. Egocentric versus Allocentric Spatial Memory in Behavioral Variant Frontotemporal Dementia and Alzheimer’s Disease.J Alzheimers Dis. 2017;59:883–92. [DOI] [PubMed]
Glikmann-Johnston Y, Mercieca EC, Carmichael AM, Alexander B, Harding IH, Stout JC. Hippocampal and striatal volumes correlate with spatial memory impairment in Huntington’s disease.J Neurosci Res. 2021;99:2948–63. [DOI] [PubMed]
Janzen G, van Roij CJM, Oosterman JM, Kessels RPC. Egocentric and Allocentric Spatial Memory in Korsakoff's Amnesia.Front Hum Neurosci. 2020;14:121. [DOI] [PubMed] [PMC]
Schmidbauer V, Nenning KH, Schwarz M, Foesleitner O, Mayr-Geisl G, Yildirim MS, et al. Imaging visuospatial memory in temporal lobe epilepsy-Results of an fMRI study.PLoS One. 2022;17:e0264349. [DOI] [PubMed] [PMC]
Dordevic M, Sulzer S, Barche D, Dieterich M, Arens C, Müller NG. Chronic, Mild Vestibulopathy Leads to Deficits in Spatial Tasks that Rely on Vestibular Input While Leaving Other Cognitive Functions and Brain Volumes Intact.Life (Basel). 2021;11:1369. [DOI] [PubMed] [PMC]
Aedo-Sanchez C, Riquelme-Contreras P, Henríquez F, Aguilar-Vidal E. Vestibular dysfunction and its association with cognitive impairment and dementia.Front Neurosci. 2024;18:1304810. [DOI] [PubMed] [PMC]
Lucieer F, Duijn S, Van Rompaey V, Pérez Fornos A, Guinand N, Guyot JP, et al. Full Spectrum of Reported Symptoms of Bilateral Vestibulopathy Needs Further Investigation-A Systematic Review.Front Neurol. 2018;9:352. [DOI] [PubMed] [PMC]
Gerb J, Brandt T, Dieterich M. A clinical 3D pointing test differentiates spatial memory deficits in dementia and bilateral vestibular failure.BMC Neurol. 2024;24:75. [DOI] [PubMed] [PMC]
Sheardova K, Laczó J, Vyhnalek M, Mokrisova I, Telensky P, Andel R, et al. Spatial Navigation Complaints are Associated with Anxiety Regardless of the Real Performance in Non-Demented Elderly.J Depress Anxiety. 2015;4:1–6. [DOI]
Pai MC, Lee CC, Yang YC, Lee YT, Chen KC, Lin SH, et al. Development of a questionnaire on everyday navigational ability to assess topographical disorientation in Alzheimer’s disease.Am J Alzheimers Dis Other Demen. 2012;27:65–72. [DOI] [PubMed] [PMC]
Laczó M, Svatkova R, Lerch O, Martinkovic L, Zuntychova T, Nedelska Z, et al. Spatial navigation questionnaires as a supportive diagnostic tool in early Alzheimer's disease.iScience. 2024;27:109832. [DOI] [PubMed] [PMC]
Gasser AI, Descloux V, von Siebenthal A, Cordonier N, Rossier P, Zumbach S. Benton judgment of line orientation test: Examination of four short forms.Clin Neuropsychol. 2020;34:580–90. [DOI] [PubMed]
Elwood RW. The Wechsler Memory Scale-Revised: psychometric characteristics and clinical application.Neuropsychol Rev. 1991;2:179–201. [DOI] [PubMed]
Zhang X, Lv L, Min G, Wang Q, Zhao Y, Li Y. Overview of the Complex Figure Test and Its Clinical Application in Neuropsychiatric Disorders, Including Copying and Recall.Front Neurol. 2021;12:680474. [DOI] [PubMed] [PMC]
Berch DB, Krikorian R, Huha EM. The Corsi block-tapping task: methodological and theoretical considerations.Brain Cogn. 1998;38:317–38. [DOI] [PubMed]
Tragantzopoulou P, Giannouli V. Spatial Orientation Assessment in the Elderly: A Comprehensive Review of Current Tests.Brain Sci. 2024;14:898. [DOI] [PubMed] [PMC]
Othman MZ, Hassan Z, Che Has AT. Morris water maze: a versatile and pertinent tool for assessing spatial learning and memory.Exp Anim. 2022;71:264–80. [DOI] [PubMed] [PMC]
Palombi T, Mandolesi L, Alivernini F, Chirico A, Lucidi F. Application of Real and Virtual Radial Arm Maze Task in Human.Brain Sci. 2022;12:468. [DOI] [PubMed] [PMC]
Plácido J, de Almeida CAB, Ferreira JV, de Oliveira Silva F, Monteiro-Junior RS, Tangen GG, et al. Spatial navigation in older adults with mild cognitive impairment and dementia: A systematic review and meta-analysis.Exp Gerontol. 2022;165:111852. [DOI] [PubMed]
Jonson M, Avramescu S, Chen D, Alam F. The Role of Virtual Reality in Screening, Diagnosing, and Rehabilitating Spatial Memory Deficits.Front Hum Neurosci. 2021;15:628818. [DOI] [PubMed] [PMC]
Mancuso V, Sarcinella ED, Bruni F, Arlati S, Di Santo SG, Cavallo M, et al. Systematic review of memory assessment in virtual reality: evaluating convergent and divergent validity with traditional neuropsychological measures.Front Hum Neurosci. 2024;18:1380575. [DOI] [PubMed] [PMC]
Llana T, Perpetuini D, Zorzo C, Mendez M. Exploring the Neural Correlates of Visuospatial Memory: A Comprehensive Review of Brain Activity Assessment in Immersive Virtual Reality Research During the Last Decade.Appl Sci. 2025;15:1881. [DOI]
Kim H, Kim Y, Lee J, Kim J. Stereoscopic objects affect reaching performance in virtual reality environments: Influence of age on motor control.Front Virtual Real. 2024;5:1475482. [DOI]
Thornberry C, Cimadevilla JM, Commins S. Virtual Morris water maze: opportunities and challenges.Rev Neurosci. 2021;32:887–903. [DOI] [PubMed]
König SU, Clay V, Nolte D, Duesberg L, Kuske N, König P. Learning of Spatial Properties of a Large-Scale Virtual City With an Interactive Map.Front Hum Neurosci. 2019;13:240. [DOI] [PubMed] [PMC]
Puthusseryppady V, Morrissey S, Spiers H, Patel M, Hornberger M. Predicting real world spatial disorientation in Alzheimer’s disease patients using virtual reality navigation tests.Sci Rep. 2022;12:13397. [DOI] [PubMed] [PMC]
Coughlan G, Puthusseryppady V, Lowry E, Gillings R, Spiers H, Minihane AM, et al. Test-retest reliability of spatial navigation in adults at-risk of Alzheimer’s disease.PLoS One. 2020;15:e0239077. [DOI] [PubMed] [PMC]
Apochi OO, Olusanya MD, Wesley M, Musa SI, Ayomide Peter O, Adebayo AA, et al. Virtual, mixed, and augmented realities: A commentary on their significance in cognitive neuroscience and neuropsychology.Appl Neuropsychol Adult. 2024:1–4. [DOI] [PubMed]
Bevilacqua R, Maranesi E, Riccardi GR, Donna VD, Pelliccioni P, Luzi R, et al. Non-Immersive Virtual Reality for Rehabilitation of the Older People: A Systematic Review into Efficacy and Effectiveness.J Clin Med. 2019;8:1882. [DOI] [PubMed] [PMC]
McKendrick R, Parasuraman R, Murtza R, Formwalt A, Baccus W, Paczynski M, et al. Into the Wild: Neuroergonomic Differentiation of Hand-Held and Augmented Reality Wearable Displays during Outdoor Navigation with Functional Near Infrared Spectroscopy.Front Hum Neurosci. 2016;10:216. [DOI] [PubMed] [PMC]
Juan MC, Mendez-Lopez M, Fidalgo C, Molla R, Vivo R, Paramo D. A SLAM-based augmented reality app for the assessment of spatial short-term memory using visual and auditory stimuli.J Multimodal User Interfaces. 2022;16:319–33. [DOI]
Gerb J, Brandt T, Dieterich M. Shape configuration of mental targets representation as a holistic measure in a 3D real world pointing test for spatial orientation.Sci Rep. 2023;13:20449. [DOI] [PubMed] [PMC]
Gerb J, Brandt T, Dieterich M. Different strategies in pointing tasks and their impact on clinical bedside tests of spatial orientation.J Neurol. 2022;269:5738–45. [DOI] [PubMed] [PMC]
Flanagin VL, Fisher P, Olcay B, Kohlbecher S, Brandt T. A bedside application-based assessment of spatial orientation and memory: approaches and lessons learned.J Neurol. 2019;266:126–38. [DOI] [PubMed] [PMC]
Hanna MG, Pantanowitz L, Dash R, Harrison JH, Deebajah M, Pantanowitz J, et al. Future of Artificial Intelligence-Machine Learning Trends in Pathology and Medicine.Mod Pathol. 2025;38:100705. [DOI] [PubMed]
Veneziani I, Marra A, Formica C, Grimaldi A, Marino S, Quartarone A, et al. Applications of Artificial Intelligence in the Neuropsychological Assessment of Dementia: A Systematic Review.J Pers Med. 2024;14:113. [DOI] [PubMed] [PMC]
Scribano Parada MP, González Palau F, Valladares Rodríguez S, Rincon M, Rico Barroeta MJ, García Rodriguez M, et al. Preclinical Cognitive Markers of Alzheimer Disease and Early Diagnosis Using Virtual Reality and Artificial Intelligence: Literature Review.JMIR Med Inform. 2025;13:e62914. [DOI] [PubMed] [PMC]
