Table Info

Table 2.

Overview of drugs used for gout flare prophylaxis

Drug	Dosing regimen for gout flare prophylaxis
Drug	Normal renal function	Advanced CKD (eGFR ≤ 30 mL/min/1.73 m²)	Dialysis	Renal transplant
Colchicine	0.6 mg once or twice daily	0.3 mg daily or 0.6 mg every other day or thrice weekly	0.3 mg twice weekly	Avoid secondary to interactions with several drugs used in transplant recipients
Prednisone	5–10 mg daily	5–10 mg daily	5–10 mg daily	5–10 mg daily
Anakinra	100 mg SC daily	100 mg SC daily or 100 mg every other day	100 mg SC daily or 100 mg every other day	100 mg SC daily
Rilonacept	160 mg SC once weekly	160 mg SC once weekly	160 mg SC once weekly	160 mg SC once weekly

CKD: chronic kidney disease; eGFR: estimated glomerular filtration rate; SC: subcutaneous

Declarations

Disclaimer

The opinions expressed in this article are those of the authors and do not necessarily represent those of the Department of Veterans Affairs or the United States Government.

Acknowledgments

The authors wish to thank Heidi Patterson, Veterans Affairs Pittsburgh Healthcare System Librarian, for the literature search.

Author contributions

JSR: Conceptualization, Writing—original draft, Writing—review & editing. NN and MR: Writing—original draft, Writing—review & editing. All authors read and approved the submitted version.

Conflicts of interest

The author declares that there are no conflicts of interest.

Ethical approval

Not applicable.

Consent to participate

Not applicable.

Consent to publication

Not applicable.

Availability of data and materials

Not applicable.

Funding

Not applicable.

Copyright

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