Overview of drugs used to treat acute gout

DrugDosing regimen for acute gout
Normal renal functionAdvanced CKD (eGFR ≤ 30 mL/min/1.73 m2)DialysisRenal transplant
Colchicine1.2 mg at onset followed by 0.6 mg one hour later. Then 0.6 mg twice daily1.2 mg at onset followed by 0.6 mg one hour later (do not repeat for 14 days)0.6 mg once at the onset (do not repeat for 14 days)Avoid secondary to interactions with several drugs used in transplant recipients
Prednisone0.5 mg/kg/day followed by a taper over a few days0.5 mg/kg/day followed by a taper over a few days0.5 mg/kg/day followed by a taper over a few days0.5 mg/kg/day followed by a taper over a few days
Anakinra100 mg SC daily for 3–5 days100 mg SC daily for 3–5 days or 100 mg every other day for 3–5 days100 mg SC daily for 3–5 days or 100 mg every other day for 3–5 days100 mg SC daily for 3–5 days
Canakinumab150 mg SC once150 mg SC once150 mg SC once150 mg SC once

CKD: chronic kidney disease; eGFR: estimated glomerular filtration rate; SC: subcutaneous