Exploration of Musculoskeletal Diseases

Table 2. Receptors inhibited by non-selective and selective uricosurics

Uricosuric	URAT1	OAT1	OAT3	OAT4	GLUT9	ABCG2	MRP4
Probenecid [6, 43]	√	√	√	–	√	–	–
Benzbromarone [6, 43]	√	√	√	–	√	–	√
Sulfinpyrazone [6, 43]	√	–	–	–	–	–	√
Lesinurad [6, 43, 55, 56]	√	√	√	√	–	–	–
Dotinurad [6, 43, 71]	√	–	√	√	–	√	–
Ruzinurad* [73, 74]	√	–	–	–	–	–	–
Pozdeutinurad (AR882)* [6]	√	–	–	–	–	–	–
Verinurad (RDEA3170)* [43, 65]	√	√	–	√	–	–	–
Epaminurad (URC102/UR-1102)* [6, 40]	√	No data	No data	No data	No data	No data	No data
ABP-671* [6]	√	No data	No data	No data	No data	No data	No data
Xininurad (XNW-3009)* [6]	√	No data	No data	No data	No data	No data	No data

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* URAT-1 inhibitors under clinical development. – indicates that the drug is not an inhibitor of the receptor. No data indicates no published data available. √ indicates target inhibited. ABCG: ATP-binding cassette super-family G; GLUT: glucose transporter; MRP4: multidrug resistance protein 4; OAT: organic anion transporter; URAT: urate transporter

Declarations

Acknowledgments

The authors thank Nicola Beadle and Emily Atkinson of Alchemy Medical Writing Ltd. for providing medical writing assistance under the direction of the authors (sponsored by Arthrosi Therapeutics Inc.).

Author contributions

RTK: Conceptualization, Writing—original draft, Writing—review & editing. ZS, SY, and LTY: Writing—original draft. MHP: Writing—original draft, Writing—review & editing. All authors read and approved the submitted version.

Conflicts of interest

RTK, ZS, SY, and LTY are all employees of Arthrosi Therapeutics Inc. MHP has consulted for Sobi and Amgen. RTK who is the Editorial Board Member of Exploration of Musculoskeletal Diseases had no involvement in the journal review process of this manuscript.

Ethical approval

Not applicable.

Consent to participate

Not applicable.

Consent to publication

Not applicable.

Availability of data and materials

Not applicable.

Funding

Not applicable.

Copyright

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