Comparison of epidemiologic and clinical characteristics of PDB and PsA

CharacteristicsPsAPDB
Age of onset, years> 45> 50
GenderF = MF = M
Familial historyPositivePositive
Vascular calcificationIs presentIs present
Involvement of weight—bearing bony architectureLower extremity enthesitis (obesity)Lower-extremities (long-bones)
PelvisPelvis
Axial spondylitisAxial skeleton
Bone ALP↑↑↑↑
CD associationYesPossibly
OCLs morphologyHypermultinucleatedHypermultinucleated
Oxidative stress
Tissue vascularity↑↑↑↑
Pattern of bone involvementAsymmetricAsymmetric
Skipping non-marginal- syndesmophytesNot crossing bone boundaries
Deep Koebner phenomenonConfirmed?
Daily trauma-related sites

DIP joints

Ray distribution

Dominant-hand thumbnail

Obesity

Skull
Environmental factorsStreptococcus/Drugs/StressMeasles virus
PrevalenceIncreasedDecreased

F: female; M: male; ↑: elevated; ↑↑: significantly elevated; ?: undetermined