Profile of bone biomarkers in RA, CD, PsA and Paget’s disease of bone (PDB)

BiomarkersRACDPsAPDB
sRANKL↑↑↑↑↑↑
OPGNL/↑
OPG ABNL/↑N/AN/A
DKK-1↑↑N/A↑/↓NL/↑
DKK-ABN/AN/AN/AN/A

sRANKL: soluble RANKL; ↑: elevated; NL/↑: both normal and elevated levels reported; ↑↑: significantly elevated; N/A: data not available; ↑/↓: both increased and decreased levels reported