Exploration of Musculoskeletal Diseases

From: Association of mutations in hemochromatosis genes with clinical severity of calcium pyrophosphate arthritis

Table 1. Comparisons between patients and controls

Variable	Cases (%)	Controls (%)	P
C-reactive protein (mg/L)	16 ± 8	4 ± 4	< 0.001
sMg (mg/dL)	1.99 ± 0.28	2.07 ± 0.23	< 0.001
HypoMg (< 1.70 mg/dL)	36/294 (12.2)	19/294 (6.5)	0.016
Ferritin (mg/dL)	257 ± 241	206 ± 173	0.004
Any HFE mutation	156/281 (55.5)	103/281 (35.6)	< 0.001
Any C282Y mutation	35/281 (12.5)	12/281(4.3)	0.001
Any H63D mutation	122/284 (42.9)	87/281 (30.9)	0.007
Any S65C mutation	6/284 (2.1)	9/281 (3.2)	0.658

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The data is represented as means ± standard deviation for continuous variables, and number/total (percentage for discrete variables)

Declarations

Author contributions

JASdB and FPR contributed eaqually to: Conceptualization, Data curation, Writing—review & editing. Nuria PH, Nerea PH, CVP, and MdCMC: Conceptualization, Writing—review & editing. All authors read and approved the submitted version.

Conflicts of interest

The authors declare that they have no conflicts of interest.

Ethical approval

The study was included within a prospective inception gout cohort study approved by Cruces University Hospital Ethics and Clinical Investigation Committee (CEIC Cruces CEIC07/15), and it complies with the Declaration of Helsinki.

Consent to participate

Informed consent to participate in the study was obtained from all participants.

Consent to publication

Not applicable.

Availability of data and materials

Data can be obtained on request by contacting Fernando Perez-Ruiz (fernando.perezruiz@osakidetza.eus).

Funding

FPR was funded by a grant from Asociación de Reumatólogos de Cruces [01/2008]. The funders had no role in study design, data collection, and analysis, decision to publish, or preparation of the manuscript.

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