From:  Safety and efficacy of non-medical switch from innovator to generic tofacitinib: a 3-month observational study in rheumatoid arthritis patients

 Rheumatoid arthritis (RA) patients’ characteristics and treatment received at the start of generic tofacitinib.

CategoryFrequency (n = 36)
Gender, n (%)
Male4 (11.1%)
Female32 (88.9%)
Age, y (mean ± SD)64.1 ± 9.4
Ethnicity, n (%)
Malay17 (47.2%)
Chinese7 (19.4%)
Indian11 (30.6%)
Other1 (2.8%)
Ever-smoker, n (%)1 (2.8%)
Obese*, n (%)13 (36.1%)
ACPA positive, n (%)28 (77.8%)
RF positive, n (%)32 (88.9%)
Duration of RA, y (IQR)15.5 (8.8–19.0)
Treatment
Duration of originator tofacitinib, y (mean ± SD)3.48 ± 1.71
Duration in rem/lda pre-switch, y (mean ± SD)2.96 ± 1.61
Concomitant csDMARDs, n (%)
Methotrexate20 (55.6%)
Sulphasalazine1 (2.8%)
Leflunomide1 (2.8%)
Not on any csDMARDs14 (38.9%)
Comorbidities, n (%)
Diabetes mellitus6 (16.7%)
Hypertension23 (63.9%)
Ischaemic heart disease1 (2.8%)
Hyperlipidaemia17 (47.2%)

ACPA: anti-citrullinated protein antibody; csDMARDs: conventional synthetic disease-modifying antirheumatic drugs; lda: low disease activity; rem: remission; RF: rheumatoid factor. *Obesity: body mass index ≥ 27.5 kg/m2.