TY - JOUR T1 - Immunization with neural-derived peptides as a neuroprotective therapy for spinal cord injury Pathophysiology after SCI A1 - Ibarra-GarcĂ­a, Andrea Paola A1 - Ibarra, Antonio Y1 - 2021/// KW - A91 KW - immunization KW - paraplegia KW - protective autoimmunity JF - Exploration of Neuroprotective Therapy VL - 1 IS - 2 SP - 111 EP - 120 DO - 10.37349/ent.2021.00009 UR - https://www.explorationpub.com/Journals/ent/Article/10049 N2 - Spinal cord injury (SCI) induces several destructive events that develop immediately after the primary insult. These phenomena increase tissue damage; that is why, numerous therapeutic approaches are studied in order to neutralize these destructive mechanisms. In line with this, several studies indicate that after injury, neural tissue could be protected by an adaptive immune response directed against self-antigens. Immunization with neural-derived peptides (INDP) reduces secondary degeneration of neurons after spinal cord insult and promotes a significant motor recovery. The combination of antioxidants or other immunomodulatory peptides after SCI can improve the protective effect induced by INDP. INDP in acute SCI is a promising strategy, so further studies should be addressed to be able to formulate the best strategy. ER -