TY - JOUR T1 - Single ‐ cell differentiation trajectories define early stages of a human cutaneous T-cell lymphoma AU - Cerapio, Juan-Pablo AU - Perrier, Marion AU - Pont, Fréderic AU - Laurent, Camille AU - Bertani, Stéphane AU - Fournie, Jean‐Jacques Y1 - 2022/// JO - Exploration of Immunology VL - 2 IS - 2 SP - 185 EP - 198 DO - 10.37349/ei.2022.00044 UR - https://www.explorationpub.com/Journals/ei/Article/100344 AB - Aim: The aim of this article is to characterize in detail the γδ T lymphocytes from an adult patient with primary cutaneous T-cell lymphoma of γδ subtype (γδ CTCL). Methods: Here this article reports trajectory mapping on high-resolution differentiation trajectories of γδ T lymphocytes digitally extracted from a scRNAseq dataset. Results: In the patch-to-plaque progression of CTCL, the TCRVγnon9 subset of γδ T cells differentiated from naive T cells (Tn) and central memory T cells (Tcm) to abundant effector memory T cells (Tem) while other cutaneous γδ T and CD8 T cells remained unchanged. Conclusions: This transcriptomic switch underlies the emergence of a CTCL-like progression of the TCRVγnon9 γδ T subtype and suggests new routes for treating these diseases. ER -