TY - JOUR T1 - Crosstalk between keratinocytes and immune cells in inflammatory skin diseases A1 - Ni, Xinhui A1 - Lai, Yuping Y1 - 2021/// KW - crosstalk KW - keratinocytes KW - immune cells KW - inflammatory skin diseases JF - Exploration of Immunology VL - 1 IS - 5 SP - 418 EP - 431 DO - 10.37349/ei.2021.00028 UR - https://doi.org/10.37349/ei.2021.00028 UR - https://www.explorationpub.com/Journals/ei/Article/100328 N2 - Cutaneous homeostasis is maintained by dynamic cellular communications between different cell types in the skin through interactions with various mediators, including cytokines, chemokines and antimicrobial peptides/proteins (AMPs). Keratinocytes, as the major cell type of the epidermis, not only form a passive physical barrier, but also actively participate in the pathogenesis of many, if not all, inflammatory skin diseases. Keratinocytes highly interact with immune cells to shape, amplify or regulate inflammatory responses, thus triggering and/or sustaining these inflammatory skin diseases. In this review, crosstalk between keratinocytes and immune cells is summarized, and its contributions to two major inflammatory skin disorders including psoriasis and atopic dermatitis are highlighted. ER -