TY - JOUR T1 - Targeting cytoskeletal phosphorylation in cancer A1 - Llorente-González, Clara A1 - González-Rodríguez, Marta A1 - Vicente-Manzanares, Miguel Y1 - 2021/// KW - actin KW - cancer KW - cytoskeleton KW - myosin KW - phosphorylation KW - tubulin KW - vimentin JF - Exploration of Targeted Anti-tumor Therapy SP - 292 EP - 308 DO - 10.37349/etat.2021.00047 N2 - Phosphorylation of cytoskeletal proteins regulates the dynamics of polymerization, stability, and disassembly of the different types of cytoskeletal polymers. These control the ability of cells to migrate and divide. Mutations and alterations of the expression levels of multiple protein kinases are hallmarks of most forms of cancer. Thus, altered phosphorylation of cytoskeletal proteins is observed in most cancer cells. These alterations potentially control the ability of cancer cells to divide, invade and form distal metastasis. This review highlights the emergent role of phosphorylation in the control of the function of the different cytoskeletal polymers in cancer cells. It also addresses the potential effect of targeted inhibitors in the normalization of cytoskeletal function. ER -