TY  - JOUR
TI  - Osteoarthritis from a female perspective
AU  - Vidal, Maritza
AU  - Lane, Nancy E
PY  - 2026
JO  - Exploration of Endocrine and Metabolic Diseases
VL  - 3
SP  - 101466
DO  - 10.37349/eemd.2026.101466
UR  - https://www.explorationpub.com/Journals/eemd/Article/101466
AB  - Osteoarthritis (OA) is the most prevalent form of arthritis and a leading cause of disability worldwide. Epidemiological studies indicate that its global prevalence is rising, particularly among women, who often experience more severe disease than men. This sex disparity is most pronounced around menopause and is influenced by female-specific biological and hormonal factors, joint morphology, reproductive history, and sex-specific comorbidities that contribute to disease onset and progression. A mechanistic understanding of these factors is essential to identify individuals at risk, implement preventive strategies, enable early diagnosis, and mitigate complications, ultimately preserving function and quality of life. This review focuses on the determinants underlying the higher incidence and severity of OA in women, highlighting the interplay between hormonal changes, anatomy, and systemic factors.
ER  -