TY  - JOUR
TI  - Anakinra for resistant Kawasaki disease in an infant: case report and literature review
AU  - Anagnostopoulou, Andriana
AU  - Andreou, Nikolaos
AU  - Tsitsami, Elena
AU  - Tsinti, Maria
AU  - Eleftherakis, Nikolaos G
PY  - 2025
JO  - Exploration of Cardiology
VL  - 3
SP  - 101271
DO  - 10.37349/ec.2025.101271
UR  - https://www.explorationpub.com/Journals/ec/Article/101271
AB  - Resistant Kawasaki has been associated with the aggressive development of large coronary aneurysms, despite prompt treatment. In this paper, we present an infant who presented with resistant Kawasaki. Although initially he seemed to defervesce after the initial administration of intravenous immunoglobulin, he developed a new onset of fever, requiring a repeat dose of immunoglobulin. Coronary aneurysms developed rapidly, necessitating a second dose of immunoglobulins and second-line treatments such as anakinra and infliximab. High titers of COVID-19 antibodies have been a confounding factor in the management of that child, as the alternative diagnosis of multisystem inflammatory syndrome in children (MIS-C) was considered. Finally, the clinical and laboratory values were more in keeping with MIS-C.
ER  -