TY - JOUR TI - Endurance sport and atrial fibrillation: a mini-review of a complex relationship AU - Costantini, Marcello AU - Elizari, Marcelo Victor AU - Previtali, Mario AU - Sciarra, Luigi AU - Luzza, Franco AU - Costantini, Lorenzo AU - Carbone, Vincenzo AU - Maffia, Michele PY - 2025 JO - Exploration of Cardiology VL - 3 SP - 101267 DO - 10.37349/ec.2025.101267 UR - https://www.explorationpub.com/Journals/ec/Article/101267 AB - Scientific evidence seems to indicate that, in males, intense and prolonged endurance sport can favor the onset of atrial fibrillation. A plausible explanation may be the impact that intense endurance sports produce on the three vertices of Coumel’s triangle. However, genetics is probably also involved in translating this impact into an arrhythmic phenotype. On a management level, the first task of the cardiologist is to exclude the presence of structural heart disease, channelopathy, endocrine and/or electrolyte disorders, and substance use. As for the treatment of arrhythmia, the “CARE” paradigm proposed by the latest ESC guidelines should probably be accompanied by detraining, although this suggestion is often rejected by the athlete. Anticoagulant therapy, where indicated, must take into account the risk of trauma that the sport entails, even if the particular pharmacodynamics/pharmacokinetics of DOACs should allow training/competition to take place when the anticoagulant effect of the previous administration has completely or almost completely worn off. ER -