@article{10.37349/ec.2025.101254,
abstract = {Aims: Evaluate the role of myocardial work by echocardiography and determine its utility as an early diagnosis of cardiotoxicity. Methods: Single-center included 180 patients over 18 years old undergoing chemotherapy, the definition of cardiotoxicity for this study was to observe a left ventricular ejection fraction (LVEF) less than 50% and, or a global longitudinal strain (GLS) less than 16%. With these parameters, we divided the population into two groups, with cardiotoxicity and without cardiotoxicity. ROC curves were performed to determine the best cut-off point for global myocardial work to define cardiotoxicity. 2 × 2 tables were made to calculate sensitivity, specificity, positive predictive value, and negative predictive value. Results: Cardiotoxicity was established by obtaining cutoff points for global myocardial work index (GWI) with values lower than 1381.5 mmHg%, Global Constructive Work (GCW) of 1722 mmHg%, and myocardial efficiency [Global Work Efficiency (GWE)] of 88.5%, with a sensitivity (52.8%, 65.6%, and 52.9%) and specificity (91.7%, 82.1%, and 89.5%) respectively. Conclusions: We propose the measurement of myocardial work as a diagnostic tool for cardiotoxicity, as it has good specificity and negative predictive value, serving as an early diagnostic tool for cardiotoxicity without waiting for a decrease in LVEF and without being a marker influenced by loading conditions, in patients undergoing antineoplastic treatment.},
author = {Cortes-Pérez, Denise and Romero-Zertuche, Diana and Rodríguez-Guzmán, Gabriela and Calixto-Guízar, Itzel and Martínez-Hernández, Carlos},
doi = {10.37349/ec.2025.101254},
journal = {Exploration of Cardiology},
elocation-id = {101254},
title = {Utility of myocardial work by echocardiography in the early diagnosis of cardiotoxicity},
url = {https://www.explorationpub.com/Journals/ec/Article/101254},
volume = {3},
year = {2025}
}