TY  - JOUR
T1  - Echocardiographic findings and subsequent risk of native valve endocarditis
AU  - Quintero-Martinez, Juan A.
AU  - Hindy, Joya-Rita
AU  - Villarraga, Hector R.
AU  - Lahr, Brian D.
AU  - Dayer, Mark J.
AU  - Thornhill, Martin H.
AU  - O'Horo, John C.
AU  - Michelena, Hector I.
AU  - Anavekar, Nandan S.
AU  - Sendi, Parham
AU  - DeSimone, Daniel C.
AU  - Baddour, Larry M.
Y1  - 2024///
JO  - Exploration of Cardiology
VL  - 2
IS  - 5
SP  - 204
EP  - 216
DO  - 10.37349/ec.2024.00034
UR  - https://www.explorationpub.com/Journals/ec/Article/101234
AB  - Aim: The association of echocardiographic findings and subsequent risk of left-sided native valve endocarditis (LS-NVE) is undefined. The aim of this study was to determine if transthoracic echocardiography (TTE) measurements are associated with the subsequent development of LS-NVE in patients without cardiac predisposing conditions. Methods: Institutional databases were evaluated for adults diagnosed with LS-NVE from 2008 to 2020. Patients with prosthetic valves, cardiovascular implantable electronic devices, intracardiac devices, injection drug use, and predisposing cardiac conditions were excluded. Only patients who had a TTE performed 6 months to 3 years before the development of LS-NVE were included as cases. Controls were patients within the same Mayo location with a TTE report and were matched in a 1:3 ratio according to age, gender, Charlson comorbidity index, and echocardiography date. Results: There were 148 cases and 431 matched controls. As compared to controls, infective endocarditis (IE) cases had a higher prevalence of diabetes mellitus (46.6% vs. 30.4%) and chronic kidney disease (46.6% vs. 28.1%) (P < 0.001). Left ventricular outflow tract velocity (P = 0.017), left ventricular ejection fraction (P = 0.018), and E:e' ratio (P = 0.050) were associated with LS-NVE. Conclusions: Echocardiographic measurements were associated with subsequent LS-NVE development in this pilot study. A larger cohort of LS-NVE patients, however, is needed to validate these findings.
ER  -