TY  - JOUR
TI  - Is bovine gelatin anaphylaxis always associated with α-Gal syndrome? Two case reports and a literature review
AU  - Guyot, Louise
AU  - Beauvillain, Céline
AU  - Lemeunier, Véronique
AU  - Bourneau-Martin, Delphine
AU  - Morisset, Martine
PY  - 2025
JO  - Exploration of Asthma & Allergy
VL  - 3
SP  - 100970
DO  - 10.37349/eaa.2025.100970
UR  - https://www.explorationpub.com/Journals/eaa/Article/100970
AB  - Gelatin is extracted from beef, pork, and fish tissues. An increasing number of cases of gelatin-induced anaphylaxis are associated with α-Gal syndrome (AGS). Only a few cases of anaphylaxis to bovine gelatin (BG) without AGS (BG-woAG) have been described. We report two new cases of anaphylaxis to BG-woAG, highlight the characteristics of this entity, and propose a procedure in cases of suspected anaphylaxis to BG. We selected articles on gelatin allergy between 1987 and 2024. Results: we report two new cases of severe anaphylaxis BG-woAG. Diagnosis was established using skin tests (ST), IgE, and basophil activation tests (BAT). We confirm the existence of allergies to BG-woAG. The main characteristic of these allergies seems to be the presence of BG IgE which differentiates them from AGS-related allergies. These initial data need to be confirmed by larger case series. We propose a diagnostic algorithm for better patient management. To confirm the diagnosis, ST and IgE to BG and α-Gal should be performed. The role of BAT to Gelofusine® in the diagnostic strategy remains to be defined.
ER  -