@article{10.37349/eaa.2025.100970,
abstract = {Gelatin is extracted from beef, pork, and fish tissues. An increasing number of cases of gelatin-induced anaphylaxis are associated with α-Gal syndrome (AGS). Only a few cases of anaphylaxis to bovine gelatin (BG) without AGS (BG-woAG) have been described. We report two new cases of anaphylaxis to BG-woAG, highlight the characteristics of this entity, and propose a procedure in cases of suspected anaphylaxis to BG. We selected articles on gelatin allergy between 1987 and 2024. Results: we report two new cases of severe anaphylaxis BG-woAG. Diagnosis was established using skin tests (ST), IgE, and basophil activation tests (BAT). We confirm the existence of allergies to BG-woAG. The main characteristic of these allergies seems to be the presence of BG IgE which differentiates them from AGS-related allergies. These initial data need to be confirmed by larger case series. We propose a diagnostic algorithm for better patient management. To confirm the diagnosis, ST and IgE to BG and α-Gal should be performed. The role of BAT to Gelofusine® in the diagnostic strategy remains to be defined.},
author = {Guyot, Louise and Beauvillain, Céline and Lemeunier, Véronique and Bourneau-Martin, Delphine and Morisset, Martine},
doi = {10.37349/eaa.2025.100970},
journal = {Exploration of Asthma & Allergy},
elocation-id = {100970},
title = {Is bovine gelatin anaphylaxis always associated with α-Gal syndrome? Two case reports and a literature review},
url = {https://www.explorationpub.com/Journals/eaa/Article/100970},
volume = {3},
year = {2025}
}